Wright State University Investigators Receive $450K to Investigate Genetic Mutations Causing Amyotrophic Lateral Sclerosis

Wright State University Investigators Receive $450K to Investigate Genetic Mutations Causing Amyotrophic Lateral Sclerosis

Principal investigator Shulin Ju and co-investigator Quan Zhong, two associate professors of biological sciences at Wright State University, received a $450,000 grant to research the neurological disease ALS. Announced by U.S. Ohio Representative Michael Turner, the three year grant supports the research into better understanding mechanisms of the cellular toxicity of the protein-coding gene FUS mutations in which cause ALS.

The Condition

Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease that starts with the progressive loss of muscle function followed by paralysis and ultimately death due to inability to breathe. There is no cure for ALS and no effective treatment to halt or reverse the progression of the disease. Most people with ALS die within three to five years from when symptoms first appear.

The Research

Professor Ju and Zhong’s research targets better understanding of the mechanisms of the cellular toxicity of the protein-coding gene FUS, mutations which cause ALS. Professor Ju explained, “Understanding why FUS is toxic and how modifier genes enable cells to survive hopefully will lead to the discovery of novel therapeutic targets, ...

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