Washington University School of Medicine’s MM3122 Crushes Remdesivir in Preclinical Lab Tests: ProteXase Therapeutics Secures IP

Preclinical researchers at Washington University School of Medicine in St. Louis (WUSTL) recently announced the development of MM3122, a chemical compound targeting the human protein known as transmembrane serine protease 2 (TMPRSS2). All known coronaviruses exploit this protein to penetrate and infect human cells. MM32122 destroyed remdesivir in a head-on comparison at the WUSTL lab. Specifically, the WUSTL preclinical compound did a superior job protecting lab-grown human cells from viral damage caused by SARS-CoV-2. Conducting preclinical safety tests on mice, large doses of the novel, pre-clinical-stage drug were administered for seven days with no material safety issues identified. Preclinical research also indicates the compound works against the first coronavirus (SARS-CoV) as well as against Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV). The researchers believe that this compound has the potential to prevent infection or reduce the severity of COVID-19 if given early in the course of an infection. The leading researcher and author of the study report, James W. Janetka, co-founded a biotech startup venture which has licensed the technology t...

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