University of Oxford-based Observational Study: COVID-19 Vaccines Don’t Help Fight Long-COVID in Breakthrough Infections

Researchers from the University of Oxford in the United Kingdom (UK) sought to investigate the effects of vaccination on long COVID—the serious condition afflicting anywhere from 10% to 30% of COVID-19 patients. In long-COVID one or more serious COVID-19 symptoms may persist for a longer period. The UK study team conducted a retrospective, cohort study as well as time-to-event analysis leveraging the TriNetX platform, a federated technology offering harmonized clinical and claims data covering hundreds of millions of real world electronic patient records. For purposes of this study the investigators were able to tap into and analyze over 81 million patient records mostly in America. Specifically, the team analyzed and compared those individuals who received a COVID-19 vaccine at least two weeks prior to SARS-CoV-2 infection then propensity score-matched those who didn’t receive a COVID-19 vaccine yet did receive the influenza vaccine. The study protocol established ICD-19 codes as outcomes representing documented COVID-19 sequelae in the six months after a confirmed SARS-CoV-2 infection between the dates of January 1, 2021, and August 31, 2021. Factoring in key data attributes suc...

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