University of Minnesota Conducts Cutting-Edge Phase 1 Clinical Trial: Gene Therapy Applied to Solid Tumors

University of Minnesota Conducts Cutting-Edge Phase 1 Clinical Trial Gene Therapy Applied to Solid Tumors

The University of Minnesota now conducts a Phase 2 clinical trial for the treatment of metastatic gastrointestinal solid tumor cancer. Exclusively conducted at the M Health Fairview University of Minnesota Medical Center, the team employs cutting-edge CRISPR genetic engineering and now is enrolling patients. This treatment, made possible by a consortia of National Cancer Institute (NCI) and University of Minnesota investigators, were the first to use CRISPR for editing a intracellular checkpoint known as Cytokine-Induced SH2 protein (CISH) in a bid to turbo charge T cells’ fight against cancer in the human clinical environment. The implications are significant as, to date, gene therapies have mostly shown promise with hematological malignancies. Now the potential to target solid tumors raises significant opportunity to address major cancers such as breast cancer, gastrointestinal cancer and lung cancer. The background to this potentially valuable investigational therapeutic involves concerted challenges to the exclusive grant of intellectual property license from NCI to the sponsor—the somewhat mysterious Intima Bioscience. TrialSite shines a little more light on the subject.


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