University of Buffalo Prepares Melatonin Trial Targeting Mild to Moderate COVID-19

University of Buffalo Prepares Melatonin Trial Targeting Mild to Moderate COVID-19

Could the natural sleep aid melatonin serve as a treatment for patients with mild and moderate COVID-19? Apparently, researchers at the University at Buffalo seek to find out, and the university Institutional Review Board granted approval to proceed. The U.S. Food and Drug Administration (FDA) already granted approval of the Investigational New Drug (IND) Application.

Any Evidence?

That melatonin would be considered for a clinical trial caught TrialSite’s attention. Hence a brief literature review.  A recent study out of Iran summarized existing evidence on melatonin therapy for viral infections with focus on underlying mechanisms of melatonin actions. In another study, a group based out of China and UT San Antonio proposes that melatonin should be included in adjuvant treatment for COVID-19 as it has proven mechanisms to target inflammasomes that trigger cytokine storms and acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2. 

The Study

Led by Sanjay Sethi, MD, director of UB’s Clinical Research Office and Deputy Director of the university’s Clinical and Translational Institute, UB’s randomized, double-blind, placebo-controlled pilot clinical trial (NCT044...

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