University of Alabama at Birmingham Observational Study: Metformin Use Leads to Three-Fold Reduction of COVID-19 Death in Patients with Type 2 Diabetes

University of Alabama at Birmingham Observational Study Metformin Use Leads to Three-Fold Reduction of COVID-19 Death in Patients with Type 2 Diabetes

In a National Institutes of Health (NIH) supported observational study, the University of Alabama at Birmingham (UAB) revealed that patients with Type 2 diabetes on the drug metformin turned out to have a three-fold decrease in mortality due to COVID-19. These patients were using the diabetes drug prior to COVID-19 diagnosis.  Led by Dr. Anath Shalev who directs UAB’s Comprehensive Diabetes Center, the study reveals that even when the study team adjusted for a number of variables (e.g. demographics or other health conditions), the beneficial correlation remained between metformin and reduction in COVID-19 death rate. As Dr. Shalev shared recently, similar findings have been discovered across populations in China, France and another UnitedHealthcare analysis. Could it be that these UAB findings are generalizable?

Could the Mechanism of Action Involve Anti-Inflammatory & Anti-Thrombotic Effects?

Recently elaborated by Jeff Hansen writing for the Alabama Newscenter, the study team doesn’t know what the mechanism of action is or how metformin actually betters a type 2 diabetes patient prognosis. They do suspect that the study results indicate that such mechanisms extend beyo...

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