Ultimovacs Announces Positive 24-month Follow-up Data from Universal Cancer Vaccine (UV1) – Pembrolizumab Combination Study in Metastatic Melanoma

Ultimovacs reported positive topline results from an ongoing U.S.-based Phase I clinical trial evaluating the Company's universal cancer vaccine, UV1, in combination with the checkpoint inhibitor pembrolizumab as a first-line treatment in metastatic malignant melanoma. The company previously reported data showing the trial reached its primary endpoint of safety and tolerability and at 24 months of follow-up UV1 and pembrolizumab continues to demonstrate strong signs of clinical response.

In the trial, patients were treated initially for 14 weeks with UV1 in combination with pembrolizumab. At the cut-off date of October 12, 2021, every patient in the first cohort had been followed for at least 24-months from the start of their treatment. The overall survival rate after two years of follow-up was 80% in this first cohort of 20 patients. As previously announced, median progression free survival for these patients was 18.9 months.

The 24-month follow-up data compares favorably with an earlier large-scale study of pembrolizumab alone, which showed an overall survival rate of 58% after 24 months and median progression-free survival of 5.5-11.6 months.

Detailed results of this o...

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