UCSF Scientist-led Study Indicates Growing Occurrence of Breakthrough Infections

TrialSite Op-ed author Geert Vanden Bossche warned public health authorities that intervening in a mass pandemic with mass vaccination could have both “detrimental and beneficial effects,” which could vary depending on age, impacted by the unfolding of events. Suggesting that while mass intervention in the pandemic may lead to short-term benefits, the action may ultimately “lead to insufficient training of innate immune mechanisms,” fundamentally appearing “in those who primarily rely on innate immunity as the first line of immune defense (i.e., children). Vanden Bossche’s dire prediction centered on the premise that mass vaccination such as what is occurring in the world’s war against SARS-CoV-2 ultimately triggers the “propagation of more infectious variants.” A negative reinforcing cycle follows as “a resurgence of viral infectious pressure, thereby eroding the innate immune defense of the unvaccinated (i.e., mostly younger age groups), making them more susceptible to disease. Now a group of San Francisco Bay Area scientists probes the association between breakthrough cases and SARS-CoV-2 variants.  Recently publishing their study in the preprint server medXriv, the authors cam...

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