UB, UCSF & UNC Make Melatonin Discovery to Someday Fix Biological Clocks

UB, UCSF & UNC Make Melatonin Discovery to Someday Fix Biological Clocks

A collaborative research team including members from University of California, San Francisco (UCSF), the University of North Carolina at Chapel Hill (UNC), and University of Buffalo (UB) have utilized a vast and novel computational library the first molecules that can modulate circadian rhythms with high selectivity to the MT1 melatonin receptor in the biological clock—located in the hypothalamus at the base of the brain. This research team pursues a key to unlocking why circadian rhythms malfunction and how the hormone melatonin, which is produced in the brain, can facilitate the development of targeted therapies that can mimic or counteract the actions of melatonin which is implicated in numerous circadian disorders ranging from depression and blindness to sleep disorders.

As reported in UBNow by Ellen Goldbaum and its publishing in the journal Nature, disorders such as insomnia and depression to obesity and bipolar disorder weak havoc on the lives of many millions of people. As it turns out, the behaviors regulated by the circadian rhythms, such as digestion and sleep-wake cycles, go unnoticed by most people but when they malfunction it can be the cause of inordinate sufferi...

Note:  If you need assistance with your subscription or would like to discuss a corporate subscription for more than 10 employees please contact us or use the chat (bottom right).

Personal
$5 / Month
Individuals at home that are reading our content for personal health care or other non-professional reasons.
Like a Starbucks a month
Personal - Single Payment
$50 for 1 Year
Individuals - reading for personal reasons who prefer to pay for one year in advance with no recurring billing.
18% discount to monthly
Professional
$12 / Month
Professionals from the healthcare industry who are subscribing on behalf of their company for work reasons.
Way better than coffee