UAB-Led Clinical Trial Investigates Reversal of Type 2 Diabetes with No Drugs

The University of Alabama at Birmingham (UAB) launched what would be considered today an unusual clinical trial addressing type 2 diabetes care in that the clinical investigators here aren’t studying the latest GLP-1 receptor agonists or SGLT inhibitors. Instead, this academic medical center in the deep south, a region of America with an enormous type 2 diabetes problem, investigates the use of diet alone to improve blood sugar control in support of remodeling the body. Led by Barbara Gower, Ph.D., professor in the Department of Nutrition Sciences, this is the first study to test a novel hypothesis that lipid stored around body organs, such as the pancreas, damage the beta cells involved with the production of insulin. Professor Gower has already demonstrated in a pilot study that material changes to what a person eats can serve to remove these lipid stores and hence, boost the first phase of insulin production in study participants at high risk for Type 2 diabetes.

The Study

Funded by the National Institutes of Health (NIH), Gower, serving as principal investigator, recruits people who have been diagnosed with T2D but are currently not using insulin. As reported by Adam Pop...

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