Spanish Pediatric Anti-MOG Study Group Discovery Could Accelerate Diagnosis & Treatment of Children with Life-Threatening Neurological Diseases

Spanish Pediatric Anti-MOG Study Group Discovery Could Accelerate Diagnosis & Treatment of Children with Life-Threatening Neurological Diseases

In observational research, a multi-center team of investigators called the “Spanish Pediatric Anti-MOG Study Group” discovered that 85% of children in a study with life-threatening autoimmune conditions had complete or near complete recovery after a specific biomarker was identified and the patients were subsequently given the appropriate treatment. This discovery originating in Spain could accelerate the diagnosis and treatment of children with life threatening diseases. The study represents a milestone in the quest to understand MOG antibody-associated syndromes.

Background

In this observational multi-center study involving 535 children with central nervous system (CNS) demyelinating disorders and encephalitis, the group of life-threatening neurological conditions affecting children were linked to an antibody which points to potential treatment. The study was published in The Lancet Neurology journal.

The findings suggest that the myelin oligodendrocyte glycoprotein (MOG) antibody is associated with a wider range of life-threatening autoimmune conditions than previously thought, including neuromyelitis optica spectrum disorders and encephalitis, which cause severe neuro...

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