Serology Tests Not Detecting Preventative COVID-19 Antibodies: Is the Public Endangered & Providers Wasting Money?

Serology Tests Not Detecting Preventative COVID-19 Antibodies Is the Public Endangered & Providers Wasting Money

Individual and public health during the COVID-19 pandemic necessitates the evaluation of potential immunity.  Consequently, the generation of antibody response to SARS-CoV-2 (seroconversion) could possibly inform on acquired immunity from past exposure. The antibodies to the SARS-CoV-2 spike protein receptor binding domain (S-RBD) are speculated to neutralize virus infection. However, some serology assays depend on assessment of SARS-CoV-2 nucleocapsid protein (N-protein) as antibody detection antigen. The problem: it is unknown if the N-protein immune response correlates with the important S-RBD response and, hence, true immunity remains unknown. Recent study results published in the JCI Insight suggests that “extensive use” of commercial serology tests from diagnostic manufactures that may serve to confirm the presence of N-protein antibodies could potentially risk misleading the public to believing, incorrectly, that they are protected from a SARS-CoV-2 reinfection. MD Anderson Cancer Center researchers caution that commercial serological tests mostly validate the presence of N-protein antibodies but the S-RBD antibodies are the best known indicator of possible protection from ...

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