Scripps Research Study Shows Investigational Antibody Therapies for Parkinson’s & Alzheimer’s Triggers Harmful Inflammation

Scripps Research Study Shows Investigational Antibody Therapies for Parkinson’s & Alzheimer’s Triggers Harmful Inflammation

Scripps Research scientist results review that experimental antibody therapies for Parkinson’s and Alzheimer’s disease actually have unintended consequences manifest in adverse events not necessarily observed in mice models of preclinical research, including brain inflammation that would probably need to be countered if these treatments are to be acceptable. While these experimental treatments target abnormal clumps of protein alpha-synuclein in Parkinson’s patients and clumps of amyloid beta protein in Alzheimer’s patients have shown success in preclinical mice models success but not so much in human-based clinical trials. And it's possible that these San Diego-based researchers now have an idea why antibody treatments aren’t working well targeting neurodegenerative disease, and the culprit appears to be brain inflammation observed in the humans. This recent study represents the first time researchers investigated antibody-induced brain inflammation in a human context for these particular indications. While the Scripps Research scientists pursue not only the harmful impact, they also develop a mitigating experimental therapy.

This recent study titled Soluble α-synuclein/antibo...

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