Rutgers Investigator Part of Team Solving How Specific Enzyme Works


Annie Kim writing for the Daily Targum reports that as antibiotic resistance becomes a growing healthcare-related problem, an international research team including Rutgers’ scientists determined how a specific enzyme’s molecular machinery in producing an important antibiotic—a key protein used by the immune system to fight bacteria. Konstantin Severinov, a principal investigator at the Waksman Institute of Microbiology and professor of Molecular Biology and Biochemistry at Rutgers—New Brunswick, studied the enzyme called McbBCD, whose job is to produce an antibody called microcin B, which is specifically deadly against E. coli bacteria. Enzymes are a type of protein, and their primary role is to speed up chemical reactions within the body. This discovery of how the enzyme functions enables scientists to now provide different adaptations of the antibiotic, which will also help to further research on new antibodies in the future.

Lead Research/Investigator

Konstantin Severinov