A sizable retrospective study involving the University of Buffalo, Aetion, Inc., HealthVerity, Inc. and the University of Toronto confirms a significant number of complications associated with COVID-19. Published in the Canadian Medical Association Journal (CMAJ), the team used de-identified outpatient and inpatient medical claims from American health databases to identify 70,288 patients who were infected with SARS-CoV-2, the virus behind COVID-19. Covering a duration from March 1 to April 30, 2020 over half of the health visits involved hospitalization, with about 5% of the total admitted into intensive care. With a median age of 65 and 55.8% female the authors studied a plethora of medical codes targeting those that increased in number post pandemic onset. Sure enough this real world evidence (RWE)-based study found that the most frequent complications associated with COVID-19 included pneumonia, respiratory failure, kidney failure and sepsis or systemic inflammation. These findings aligned with other observations. Overall, the risk associated with a patient with COVID-19 succumbing to these more serious ailments equaled 27.6% for pneumonia, 22.6% for respiratory failure, 11.8% kidney failure and 10.4% associated with sepsis or systemic inflammation.
Additionally these researchers found other real world evidence, although rare in association with COVID-19, such as a range of other conditions associated with COVID-19 such as collapsed lung, blood clotting disorders and heart inflammation. COVID-19 isn’t associated with a higher risk of stroke according to this study. The study can be found here.
Investigator Point of View
Dr. William Murk, Jacobs School of Medicine & Biological Sciences, University of Buffalo, reported, “Understanding the full range of associated conditions can aid in prognosis, guide treatment decisions and better inform patients as to their actual risks for the variety of COVID-19 complications reported in the literature and media.”
Who are the Sponsors?
TrialSite reports often on University of Buffalo and University of Toronto they are one of the busier research centers in the United States. Aetion, Inc. is a health care technology company delivering real-world evidence for life sciences, payers, providers and regulatory agencies. The Aetion Evidence Platform analyzes data from the real world to produce transparent, rapid and scientifically validated answers on treatment costs and outcomes. Founded in 2013, this company has raised over $93 million in investment capital.
Meanwhile, HealthVerity Inc. enables the creation and execution of unique end-to-end strategies with privacy and HIPAA-compliance at the forefront. The company supports workflow and analysis of large data sets in a complaint manner.
Dr. William Murk, Jacobs School of Medicine & Biological Sciences, University of Buffalo
Call to Action: Follow the link to review the study.