Promising University of Alabama Medicine Real-World Study Indicating Effective COVID-19 mRNA-based Vaccines

Over 250 University of Alabama, Birmingham (UAB) Medicine employees recently participated in a real world study investigating the effectiveness of both mRNA-based COVID-19 vaccines developed by Pfizer-BioNTech and Moderna.  Published in the New England Journal of Medicine on September 22, substantial benefit was discovered at 96% for the Moderna vaccine and 89% for the Pfizer vaccine. This was part of a nationwide multi-site study investigating overall vaccine effectiveness in health care workers.


This research endeavor was called Project PREVENT, a U.S. Centers for Disease Control and Prevention (CDC) sponsored effort involving the collection of data associated with 5,000 health care workers around the country who happened to have been tested for SARS-CoV-2 between the dates of December 2020 till May 2021. The UAB Medicine site involved over 250 participants.

The study made use of employee testing protocols for COVID-19 at 33 participating medical centers in the United States, enrolling 1,482 cases and 3,449 controls. The cases, participants who were symptomatic and tested positive for COVID-19, were compared to the controls, people with COVID-like sympto...

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