PhaseBio Announces Topline Results from Phase 2b Trial for Bentracimab in Reversing Antiplatelet Activity of Ticagrelor

PhaseBio announced topline data from its Phase 2b clinical trial of bentracimab, which was conducted in healthy, older volunteers 50-80 years old. The multi-center, randomized, double-blind, placebo-controlled study enrolled 150 subjects receiving bentracimab and 50 subjects receiving placebo after all were pretreated with dual antiplatelet therapy composed of ticagrelor and low-dose aspirin. The Phase 2b pivotal trial was conducted concurrently with the company’s ongoing REVERSE-IT Phase 3 pivotal trial of bentracimab.

The trial achieved its primary endpoint, reversal of ticagrelor’s inhibition of platelet function in actively treated subjects versus placebo as measured using the point-of-care VerifyNow PRUTest platelet function assay (VerifyNow).

A prespecified interim analysis from the REVERSE-IT trial will be presented on Monday, November 15, 2021, during a late-breaking science session at the American Heart Association’s Scientific Sessions 2021. The Company is commencing preparation of a Biologics License Application (BLA) and, pending results of REVERSE-IT, is targeting a BLA submission to the FDA in mid-2022.

About Bentracimab

Bentracimab is a novel, reco...

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