Patients with Cerebral Venous Sinus Thrombosis in COVID-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia

Reports of COVID-19 vaccination adverse events, specifically thrombosis with thrombocytopenia syndrome (TTS) associated with either the Oxford-AstraZeneca vaccine (ChAdOx1 nCov-19) and Janssen/Johnson & Johnson (Ad26.COV2S), raised notice among physician specialists around the world. A group of experts affiliated with the Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group organized a study manifesting in an international registry of patients with cerebral venous sinus thrombosis (CVST) after they received a SARS-CoV-2 vaccination. They sought to understand better the clinical characteristics and outcomes of patients with CVST with TTS (CVST-TTS). Specifically, they sought to test whether patients with CVST-TTS would present clinical features and a degraded prognosis; in parallel, they studied patients with postvaccination CVST without TTS suggesting a clinical profile in this cohort similar to patients with CVST pre-COVID-19 pandemic.

In this study, the investigators describe the clinical characteristics and outcomes of patients diagnosed with CVST post-COVID-19 vaccination with and without TTS. TrialSite provides a brief summary breakdown for the c...

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