Systematic Meta-Analysis Globally Shows SARS-CoV-2-Triggered MIS-C Hit Children Hard, Significant Number of Deaths

Giancarlo Alvarado-Gamarra at the pediatric department in the General Hospital in Jesús María District, Lima, Peru, and colleagues report on the serious post-infectious condition linked to COVID-19 in young persons: multisystem inflammatory syndrome in children or MIS-C. With existing studies concentrating on MIS-C severity leading to various outcomes, the Peruvian authors acknowledge the difficulty to date to draw any conclusions. Enter this systematic review finding that although a low certainty evidentiary baseline, the authors find the frequency of in-hospital unfavorable outcomes in patients with MIS-C is high. Reflecting a more globalized and generalizable output, the authors introduce the world to just how severe MIS-C has been during the pandemic. Importantly authorities promoted vaccination among children, especially during the delta surge, to mitigate the risk of MIS-C.

TrialSite has chronicled studies revealing that MIS-C emerged as most severe during the delta variant of interest surge. Alvarado-Gamarra and colleagues sought to estimate the frequency of in-hospital unfavorable outcomes in patients with MIS-C over the 3 years since the onset of the SARS-CoV-2 pandemic.