Breakthrough Nasal Spray Could Delay Alzheimer’s Progression by Over a Decade

Scientists at Texas A&M University College of Medicine have developed an anti-Alzheimer's nasal spray that could delay the progression of the disease by over ten years. The research has been published in the Journal of Extracellular Vesicles.

The pathological changes associated with cognitive and mood impairments in Alzheimer's disease (AD) include lasting neuroinflammation, the formation of amyloid-beta (Aβ) plaques, neurofibrillary tangles, synapse loss, tau deposits and neurodegeneration. Current therapeutic strategies for AD are not efficacious in slowing its progression, said the researchers, highlighting the need for novel therapies that can ease the progression of multiple pathological changes, including neuroinflammation, and maintain better cognitive and mood function for extended periods after initial AD diagnosis.