Oregon State University Team Pursue Microbiota Keys to Someday Treating Obesity—Hops Trigger Important Bacteria in Gut

Researchers at Oregon State University (OSU) reveal recently research evidencing how a compound found in hops (xanthohumol) may depend on interactions with intestinal microorganisms as part of a broader investigation into how to counter diet-induced obesity and health risks associated with the global obesity epidemic—including type 2 diabetes, liver, and heart disease. Led by Adrian Gombart, a team of 20 scientists from three Oregon State colleges compared the glucose metabolism effects of the xanthohumol on two sets of mice, including 1) “conventional” ones with gut microbiota and 2) those engineered to be “germ-free,” meaning they have no gut microbes. Importantly this group of microbiome focused researchers seek to better understand how xanthohumol (XN) works in their investigation to unlock the compound’s potential to fight obesity—a true epidemic at this point. According to Dr. Adam Gombart, Principal Investigator, Linus Pauling Institute, OSU, “… gut microbiota is necessary for the beneficial effects of XN on glucose metabolism.” Put another way, the preclinical research using mice finds that the interaction between XN and microbes in the gut offers the subjects (in this cas...

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