Northern Arizona University Lab Results Reveal Promising Antiviral Targeting COVID-19, Including Delta Variant

Northern Arizona University Lab Results Reveal Promising Antiviral Targeting COVID-19, Including Delta Variant

A team of scientists from Arizona, USA, Germany, and Denmark recently published the findings of early-stage, preclinical laboratory studies indicating that a poly (ADP-ribose) polymerase (PARP) inhibitor known as stenoparib or “2X-121” is under development by a Danish biotech. It was upblished in the preprint server bioRxiv. Researchers from Northern Arizona University’s Pathogen and Microbiome Institute in Flagstaff, as well as a contract research organization (CRO) called Viroclinics—DDL in Rotterdam, The Netherlands, and Allarity Therapeutics based in Hørsholm, Denmark demonstrated that stenoparib effectively inhibits additional SARS-CoV-2 variants—from an additional wild-type strain (Germany/BavPat1/2020) as well as select common variants alpha (B.1.1.7) and beta (B.1.351) as well as gamma (P.1) in vitro with a 50% effective concentration (EC) estimates of 4.1 μM, 8.5μM, 24.2 uM, and 13.6μM respectively. The authors shared in their output a second study centering on the combination of stenoparib and remdesivir, which resulted in an over 90% inhibition of alpha (B.1.1.7) variant, substantially superior to what was achieved with either one of those alone. Recently, the company a...

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