Chinese study looks into cognitive symptoms in major depressive disorder; associations with clinical and functional outcomes in a 6-month, non-interventional, prospective study in China.
The Study Objectives
The Chinese researchers sought to better understand common cognitive symptoms in major depressive disorder (MDD) and how they negatively impact clinical and functional outcomes. The Prospective Research Observation to Assess Cognition in Treated patients with MDD (PROACT) study an aimed to assess the prevalence and course of cognitive symptoms, and their associations with clinical and functional outcomes during 6 months of antidepressant treatment, in a real-world setting among Chinese patients with MDD
At baseline, 76.9% of patients had indications of cognitive symptoms (PDQ-D total score ≥21; at month 6, this was reduced, but still present in 32.4%. Across the 6-month study period, patients improved across cognitive, clinical and functional assessments. High levels of cognitive symptoms (PDQ-D) consistently predicted worse clinical outcomes, i.e. lower odds for remission and increased odds for relapse, as well as worse patient-reported functional outcomes and lower quality of life. In contrast, cognitive performance (DSST) predicted performance-based functioning but only a few patient-reported functional outcomes (absenteeism and quality of life), and no clinical outcomes. PDQ-D and DSST scores were uncorrelated at baseline.
The study highlights the importance of assessing and targeting cognitive symptoms for increasing patients’ chances of recovery and restoring in the treatment of MDD. The results further highlight the relevance of complementary assessment methods to fully capture aspects of cognitive symptoms in patients with depression.
Beijing An Ding Hospital, Capital Medical University, China National Clinical Research Center for Mental Disorders, Beijing, People’s Republic of China
Peking University Sixth Hospital & Peking University Institute of Mental Health, Beijing, 100191, People’s Republic of China
Key Laboratory of Mental Health, Ministry of Health (Peking University) &National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, People’s Republic of China
The Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Beijing Tian Tan Hospital, Department of Neuropsychiatry and Behavioral Neurology, Capital Medical University, National Clinical Research Center for Neurological Disease, Beijing, People’s Republic of China
Tianjin Anding Hospital, Tianjin, People’s Republic of China
Lundbeck Singapore Pte Ltd, Singapore
H. Lundbeck A/S, Valby, Denmark;
Lundbeck China, Beijing, People’s Republic of China