NIAID, Roche & Novartis Partner on Clinical Trial to Evaluate Experimental Food Allergy Trial

NIAID, Roche & Novartis Partner on Clinical Trial to Evaluate Experimental Food Allergy Trial

The National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH, has partnered with Genentech (Roche) and Novartis to conduct a new study to evaluate an experimental treatment for food allergies.
The Problem
More than 4.8 million children in the United States suffer from food allergies. Not one approved preventative treatment exists.  Although experimental desensitization strategies are present in research settings, people with food allergies must avoid known allergens and are advised to carry injectable epinephrine to prevent potentially life-threatening allergic reactions caused by accidental exposures.
The Study
Called Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergan Oral Immunotherapy in Food Allergic Children and Adults, or OUtMATCH, the study will test the ability of biweekly or monthly injections of omalizumab—alone or together with multi-allergen oral immunotherapy (OIT) to increase a person’s ability to tolerate foods to which they are allergic. Multi-allergen OIT involves consuming small, gradually increasing amounts of several allergens in a controlled setting to build the body’s tolerance to those food allergens. Investigators wi...

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