NCCN Awards Grants to Investigators to Study Trifluridine & Tipiracil

P&T Community reports that the National Comprehensive Cancer Network (NCCN) Oncology Research Program has awarded grants to three clinical investigators from NCCN member institutions through a collaborative scientific research relationship with Taiho Oncology, Inc. to study the clinical effectiveness and safety of trifluridine and tipiracil (TAS-102) for treatment of various advanced, solid tumors. The investigators include:

Patrick Boland, MD Rosewell Park Comprehensive Cancer Center, a Phase II Study of TAS-102 Irinotecan and Bevacizumab in Pre-treated Metastatic Colorectal Cancer (TABAsCO)
Amit Mahipal, MBBS, Mayo Clinic Cancer Center, Phase II Trial of trifluridine/tipiracil in Combination with Irinotecan in Biliary Tract Cancers
Sarbajit Mukherjee, MD, MS, Roswell Park Comprehensive Cancer Center, Use of Trifluridine/tipiracil and Oxaliplatin as Induction Chemotherapy in Respectable Esophageal and Gastroesophageal junction (GEJ) Adenocarcinoma

What is TAS-102?

Approved by the FDA in 2015 and EMA in 2016, trifluridine/tipiracil (trade name Lonsurf) is a combination drug that is approved for use as a third- or fourth-line treatment of metastatic colorectal c...

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