mRNA Vaccine Invention Timeline: Historical Fact Check

The recent piece in Nature titled “The tangled history of mRNA vaccines” unfortunately missed some key facts in the unfolding history of this fascinating and important topic. Based on our research, the timeline and inventorship of the first animal experiments misses the mark. Actually, the first proof of principle experiment of mRNA vaccination in animal model occurred back in 1989 and 1990 by inventors of the original patents, which includes Dr. Robert Malone. The proof of principle experiment in animals is discoverable in the first patents. After all, haven't patents always been a method of establishing inventorship? An approved patent must have clear scientific data to back the claims, of course. A claim for a patent is never approved on an idea. It must be reduced to practice. The foundation of patent law, in the case of mRNA, the claims approved, are clearly indicated for mRNA vaccination.

So we find that in the Nature piece, the authors declare that the first animal experiment was undertaken in 1992 by a wholly different group.  We believe this is a mistake on the part of the authors.

Based on our research, a patent was filed under Vical for mRNA vaccination in an...

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