Chinese investigators pursued research published in Dovepress. They report that there is mounting evidence to indicate that microRNA-17 (miR-17) is expressed and functionally involved in human cancers. However, the molecular mechanism underlying the role of miR-17 in colorectal cancer (CRC) remains largely unclear. The researchers sought to reveal the biological function of miR-17 in CRC.
Post study, the investigators concluded that unregulated miR-17 may promote progression of CRC and may exert its function as a tumor suppressor miRNA by targeting SIK1.
The research effort is the result of a collaboration among dozens of Chinese research institutions.