MicroRNA-17 Promotes Cell Proliferation & Migration in CRC by Downregulating SIK1

Apr 25, 2019 | Biomarker, Cancer, Colorectal Cancer, Oncology, Tumors

Chinese investigators pursued research published in Dovepress. They report that there is mounting evidence to indicate that microRNA-17 (miR-17) is expressed and functionally involved in human cancers. However, the molecular mechanism underlying the role of miR-17 in colorectal cancer (CRC) remains largely unclear. The researchers sought to reveal the biological function of miR-17 in CRC.

Post study, the investigators concluded that unregulated miR-17 may promote progression of CRC and may exert its function as a tumor suppressor miRNA by targeting SIK1.

The research effort is the result of a collaboration among dozens of Chinese research institutions.


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