Merck’s Peloton Therapeutics Purchase: Taking the Novel UT Southwestern to the Global Stage


TrialSite News covered the Merck acquisition of Peloton Therapeutics (Peloton). As the Dallas TX-based venture published an S-1 in anticipation of going public, we offered a brief summary of this venture heavily infused with UT Southwestern-born innovation. In this brief, we provide more detailed information on the transaction and Peloton itself. Merck announced its acquisition of Peloton Therapeutics, a clinical-stage biopharmaceutical company focused on the development of novel small molecule therapeutic candidates targeting hypoxia-inducible factor-2α (HIF-2α) for the treatment of patients with cancer and other non-oncology diseases. Peloton’s lead candidate PT2977, is a novel oral HIF-2α inhibitor in late-stage development for renal cell carcinoma (RCC) (kidney cancer).

Merck’s Rational

Dr. Roger M. Perlmutter, president Merck Research Laboratories stated, “This acquisition exemplifies Merck’s strategy to pursue novel therapeutic candidates based on exceptionally promising and innovative research” and explained, “Peloton scientists have applied their unique expertise in HIF-2α biology to develop PT2977, which has already shown intriguing activity in the treatment of ren...

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