Ludwig Center & Lustgarten Laboratory Develop Revolutionary Cancer Detection Screening Technology

Ludwig Center & Lustgarten Laboratory Develop Revolutionary Cancer Detection Screening Technology

Researchers from Ludwig Center and Lustgarten Laboratory at the Johns Hopkins Kimmel Cancer Center have developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application. Now thanks to a breakthrough involving next-generation gene sequencing (NGS) technologies, where millions of DNA molecules are simultaneously but individually analyzed, tihs theoretically provides researchers and clinics the ability to noninvasively identify mutations in the bloodstream. Identification of such mutations could enable earlier diagnosis of cancer while informing providers as to treatment decisions. In a quest to dramatically improve this approach, including the correction of sequencing errors, the research team has developed SaferSEeqS (Safer Sequencing System) representing a major advancement to widely used technologies based on a previous technology called SafeSeqS (safe sequencing system) that Johns Hopkins investigators invented a decade ago. This new SaferSeqS technology detects rare mutations in blood in a highly efficient manner, while reducing the error rate of commonly use...

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