Large RWE Study: Famotidine (Pepcid) May Have Saved Hundreds of Thousands of Lives During COVID-19 Pandemic

A cutting-edge federated technology-powered network known as TriNetX powered an impressive real-world evidence study involving approximately 400 million patients across 30 countries. Based on a federated, distributed model the system pulls electronic medical records—that is from diagnoses and procedures to medications and more—in an aggregated format supporting deep analytics of the de-identified patient data. American and German researchers represent the University of Virginia at Charlottesville and Charité–Universitätsmedizin Berlin analyzed a cohort of 22,560 COVID-19 patients receiving H1/H2 receptor antagonists, with a special focus on 1,379 severe cases requiring respiratory support. Establishing mortality as a primary endpoint the researchers explained they hoped to mitigate cofounder by employing propensity-score matching with a goal of “stratified and balanced sub-cohorts across age and gender.” What they found was stunning. Among other benefits famotidine provided what the authors declared was “an immense benefit” to COVID-19 patients.

Famotidine Background

Known for its trade name Pepcid, this drug is a histamine H receptor antagonist medication reducing...

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