Jardiance Achieves Primary Endpoint in EMPEROR-Preserved Phase 3 Trial in Patients with Heart Failure with Preserved Ejection Fraction

Jardiance Achieves Primary Endpoint in EMPEROR-Preserved Phase 3 Trial in Patients with Heart Failure with Preserved Ejection Fraction

Boehringer-Ingelheim and Eli Lilly announced top-line results from the phase 3 EMPEROR-Preserved trial. The trial met its primary endpoint and demonstrated significant risk reduction with Jardiance for the composite of cardiovascular death or hospitalization for heart failure in adults with heart failure with preserved ejection fraction. Full results from the EMPEROR-Preserved trial are scheduled for presentation at the European Society of Cardiology (ESC) Congress 2021 on August 27. Boehringer Ingelheim and Lilly plan for regulatory submissions in 2021.

The randomized, double blind trial investigated the safety and efficacy of Jardiance 10 mg versus placebo in 5,988 patients with chronic heart failure with preserved ejection fraction (HFpEF). The analysis from EMPEROR-Preserved align with previously reported results from the EMPEROR-Reduced phase III trial, which showed that Jardiance significantly reduced the combined relative risk of cardiovascular death or hospitalization for heart failure by 25% compared to placebo in adults with heart failure with reduced ejection fraction (HFrEF). Together, these studies demonstrate the b...

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