IVERCOVID19 Study in Argentina Disappoints—Study Underdoses & Ivermectin Comes Up Short

IVERCOVID19 Study in Argentina Disappoints—Study Underdoses & Ivermectin Comes Up Short

A much-awaited ivermectin study in Argentina disappointed those looking for positive results as the IVERCOVID19 trial, sponsored by the Corrientes Institute of Cardiology “Juana F. Cabral” with funding from the Ministry of Public Health, Province of Corrientes, Argentina, came out with subpar results. The single-center, prospective, randomized, double-blind, placebo-controlled study centered on the primary endpoint as the need for hospitalization in patients with COVID-19 while secondary endpoints involved time to hospitalization in days, use of invasive mechanical ventilation, time to invasive mechanical ventilation in days, use of dialysis, and all-cause mortality. The study team acknowledged material limitations, including first that the study was underpowered but secondly and importantly the acknowledgment that the dosage was “below the doses proposed as probably effective.” Consequently, the study authors reported in the peer review journal BMC Infectious Diseases that at least in this study group, the drug had no significant effect on preventing the hospitalization of patients with COVID-19. As it turned out, those that did require invasive mechanical ventilation frequented ...

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