Italian Government Agency Declares Use of Hydroxychloroquine for Off-Label Against COVID-19 Legal: Revolt of the Doctors?

Italian Government Agency Declares Use of Hydroxychloroquine for Off-Label Against COVID-19 Legal: Revolt of the Doctors?

As TrialSite recently reported, the anti-malarial drug, originally a key focus in the response against COVID-19, but shortly after, when US POTUS marketed the drug publicly, was the center of political and scientific controversy. A number of studies led to the conclusion that the drug wouldn’t be effective, and there were even calls that some cardiovascular risks were apparent for at least some cohorts. The drug, already approved by the U.S. Food and Drug Administration (FDA), has a well-known profile. Interestingly, a good number of studies evidenced some positive findings, but critics quickly pointed out flaws in those studies. The pro-hydroxychloroquine camp always pointed out that the drug should be used as either A) early onset of COVID-19 cases (not in hospitalization stages as many studies had done) or even B) as PrEP (pre-exposure prophylaxis). Interestingly, the global research community recently opted to keep the drug at the center of investigational interest with the ANTICOV study in Sub-Saharan Africa, evidencing the continued interest in the drug as an early-stage treatment. That is, at least in the developing world. Now, the Italian Council of State reportedly issued...

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