Institut Pasteur Preclinical Study: Ivermectin a Powerful Immunomodulatory Drug Targeting SARS-CoV-2

Institut Pasteur Preclinical Study: Ivermectin a Powerful Immunomodulatory Drug Targeting SARS-CoV-2

A prestigious global research institute based in France has published a preclinical study in EMBO Molecular Medicine revealing that ivermectin is associated with a reduction in COVID-19 symptoms. Yet even after dozens of studies showcasing such results in real-world scenarios, the World Health Organization (WHO) has yet to embrace the opportunity of the drug for low-and middle-income countries (LMICs). Institut Pasteur’s Jean-Pierre Changeux suggests the drug acts on the nicotinic receptor, leading to what undoubtedly will fuel an interesting debate on the topic. In a comprehensive preclinical study involving hamsters, the study team concluded that ivermectin represents a powerful immunomodulatory drug, implying that it could help the world in its fight against the COVID-19 pandemic. The study results reveal that the anti-parasitic drug ivermectin prevents clinical deterioration, reduces olfactory deficit, and limits the inflammation of the upper and lower respiratory tracts in the study animals. The investigators recommend consideration of the drug as a means to combat COVID-19.

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