Indian and Saudi Researchers Identify HIV Drug Zidovudine (GSK’s Retrovir) as Potential Therapy Targeting COVID-19

Indian and Saudi Researchers Identify HIV Drug Zidovudine (GSK’s Retrovir) as Potential Therapy Targeting COVID-19

An international team of researchers from Saudi Arabia’s Shaqra’s University, India’s AIIMS and America’s Johns Hopkins University have identified three potential drug molecules that could target SARS-CoV-2, the virus behind the COVID-19. One of the targets, Zidovudine (Retrovir), is already prescribed for HIV patients. The team have also been studying 3D models of SARS-CoV-2 and have pinpointed sites for improved drug delivery.    

The Study

Published in the Journal of Biomolecular Structure and Dynamics, the team utilized virtual screening, molecular modeling and analysis of drug molecules reactions against target proteins on COVID-19. The team identified three potential targets, including two unnamed molecules, and Zidovudine, a drug used for HIV, emerged as a strong contender for clinical trials. According to Yadav from AIMMS, the group plans on approaching PGIMER Chandigarh to explore a prospective collaboration involving laboratory investigations into the effectiveness of Zidovudine against SARS-CoV-2.

3D Models of SARS-CoV-2

The research team, including Dr. Shailendra Handua, who leads pharmacology at AIIMS/Rishikesh and Dr. Puneet Dhamija who participated in th...

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