Hoag’s Pickup Family Neurosciences Institute Opens Clinical Trial for Drug that Aims to Slow Alzheimer’s

Hoag’s Pickup Family Neurosciences Institute Opens Clinical Trial for Drug that Aims to Slow Alzheimer’s

Hoag, a nonprofit, regional health care delivery network in Orange County, California, recently announced that the Pickup Family Neurosciences Institute initiated a clinical trial for a therapy that can potentially slow Alzheimer’s disease and now enrolls patients in the Phase 3 clinical trial known as TRAILBLAZER-ALZ 2, involving an investigation into the efficacy and safety of a novel treatment aimed at the early symptom phase of Alzheimer’s disease (AD). Investigating the use of Eli Lilly’s donanemab, the drug has shown significant ability over the last handful of years, including the clearance of 80% of amyloid in preclinical experiments and, more recently, met the endpoints of a major Phase 2 study known as TRAILBLAZER-AZ. The investigational treatment targets and removes deposited amyloid plaque, which is one of the two signature markers of AD in the brain. The Phase II trial found that patients who received the treatment scored better on tests of cognition and ability to perform daily activities than those given a placebo. Researchers also found a significant decrease in both amyloid and tau, the other markers of AD, on PET scans in patients who received the investigational...

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