Inactivated Virus Vaccine (Sinopharm or Sinovac) side-effects

  • Inactivated Virus Vaccine (Sinopharm or Sinovac) side-effects

     nena updated 2 weeks, 2 days ago 2 Members · 3 Posts
  • nena

    Member
    September 3, 2021 at 7:28 pm

    Please share any studies or information on the safety profile and side-effects of Inactivated Virus Vaccine (Sinopharm or Sinovac). Thank you

  • skepticsembracefailure

    Member
    September 5, 2021 at 7:18 am

    Here’s some data from a WHO report on Sinopharm. Clinical trial follow-up almost 4 months and the only death was in the placebo group. Very impressive except that they enrolled only <2% over age 60, which is much less than in the trials for other (i.e. US) vaccines, and deaths apparently caused by US vaccines seem to be concentrated in older people although some deaths occur in younger people also (of course, non-fatal side effects from US vaccines are very important and do affect younger people).

    https://cdn.who.int/media/docs/default-source/immunization/sage/2021/april/2_sage29apr2021_critical-evidence_sinopharm.pdf

    Here’s a Phase 3 clinical trial on Sinovac published in Lancet. No deaths at all in the study, but median follow-up was only 43 days! They also don’t seem to have enrolled anyone over 60.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266301/

    Now there is another inactivated virus vaccine called Covaxin from India (available in Mexico and a few Asian and African countries), which did have a significant fraction of older people included in its trial, and the median follow-up was 5 months. Check out the death totals in the preprint article of
    Covaxin’s randomized blinded clinical trial here (5 vaccine, 10 placebo)- that is extremely impressive.
    https://www.medrxiv.org/content/10.1101/2021.06.30.21259439v1. At least up to 5-6 months, Covaxin actually appears to save lives (reduce total deaths) unlike Pfizer which was proven to slightly increase total deaths in its own clinical trial (15 vaccine, 14 placebo)- see Pfizer’s preprint article here https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1. And we can be almost 100% sure Moderna is worse than Pfizer based on VAERS death rates and the 3.33x higher vaccine dose with Moderna than Pfizer. Most interestingly, you can see that the US all but curtailed administration of Moderna (which was partly developed by the NIH!), around May based on this graph here https://ourworldindata.org/grapher/covid-vaccine-doses-by-manufacturer?country=~USA. The sad, brutal reason I can think of is that they realized it’s killing people significantly more than Pfizer.

    So in summary, all the data points to inactivated virus vaccines like Sinopharm and Sinovac being much safer than US vaccines like Pfizer or Moderna, but I say this partly based on extrapolation from Covaxin’s trial, since the Sinopharm/Sinovac trials hardly enrolled anyone over 60. I think there is also some data from Europe (Hungary?) and Mexico showing a lower total death rate and serious adverse event rate with Sinopharm than Pfizer or Moderna.

  • nena

    Member
    September 6, 2021 at 12:17 pm

    @skepticsembracefailure – THANK YOU! This is tremendously useful. Please continue to post if you find new information. I read that Covaxin may receive WHO EUA as soon as mid-September: https://economictimes.indiatimes.com/news/india/who-to-review-covaxin-emergency-use-approval-may-come-by-mid-sept/articleshow/85815599.cms

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