Gene Therapy Reverses Deafness in Mice

Institut Pasteur scientists have managed to restore hearing in an adult mouse, a model of DFNB9 deafness -- a hearing disorder that represents one of the most frequent cases of congenital genetic deafness. Individuals with DFNB9 deafness are profoundly deaf as they are deficient in the gene coding for otoferlin, a protein which is essential for transmitting sound information at the auditory sensory cell synapses.

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