Fox Chase Cancer Center Investigator Pursues an Understanding of how Malnutrition & Physical Inactivity may Adversely Impact Oncology Clinical Trials Data

Fox Chase Cancer Center Investigator Pursues an Understanding of how Malnutrition & Physical Inactivity may Adversely Impact Oncology Clinical Trials Data

Researchers from Fox Chase Cancer Center, Philadelphia PA report that cancer-focused clinical trials may be generating inaccurate trial results. Why? The nutritional status and body composition of advanced cancer patients participating in these trials may need further evaluation. The study has found that patients who are malnourished for example, may experience more adverse events from the investigational therapy, not to mention higher rates of hospitalization and lower response rates and overall shortened survival.

Recently reported in Oncology Nurse Advisor, the lead author of this study, Rishi Jain, MD, assistant professor, Department of Hematology/Oncology with Fox Chase Cancer Center, noted adverse outcomes are forecasted with patients dealing with malnutrition, and that the magnitude of this effect was alarming. He was quoted, “There was (an approximately) twofold increased risk of hospitalizations and severe side effects in those who were malnourished. Also, patients who were malnourished were only able to stay on the clinical trial study for half as long.”

The Study

Dr. Jain and colleagues recruited 100 patients (54% male, 46% female) between July 2016 and Ma...

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