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  • Virucidal gargling and virucidal nasal spray

    Avatar IveyTech updated 1 week ago 1 Member · 2 Posts
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    IveyTech

    Member
    May 1, 2021 at 8:03 pm

    We can go beyond the advice of masking, distancing and washing. There are some really simple ways to help keep from harboring SARS-CoV-2 in our nose and throat mucus and saliva.

    “In summary, we provide evidence that SARS-CoV-2 can be efficiently
    inactivated by commercially available oral rinses within short exposure
    times of 30 seconds.”

    Abstract

    “The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic creates a significant threat to global health. Recent studies suggested the significance of throat and salivary glands as major sites of virus replication and transmission during early coronavirus disease 2019, thus advocating application of oral antiseptics. However, the antiviral efficacy of oral rinsing solutions against SARS-CoV-2 has not been examined. Here, we evaluated the virucidal activity of different available oral rinses against SARS-CoV-2 under conditions mimicking nasopharyngeal secretions. Several formulations with significant SARS-CoV-2 inactivating properties in vitro support the idea that oral rinsing might reduce the viral load of saliva and could thus lower the transmission of SARS-CoV-2.”

    DISCUSSION

    “The main route of transmission of SARS-CoV-2 is suspected to involve direct contact with respiratory aerosols or droplets of infected individuals, produced during sneezing, coughing, or talking, and subsequent contact to nasal, oral, or ocular mucosal membranes [1]. SARS-CoV-2 initially colonizes the upper respiratory tract of infected individuals [2]. High viral loads in the oral cavity provide a rich source of potentially infectious virus as well as an entry route for new infections. Hence, if assuming that the throat functions as a major site of viral replication during early stages (even before symptom onset), oral antisepsis could lower the number of infectious aerosolized virus particles and consequently the risk of transmission or infection. Experimental and clinical research studies on SARS-CoV-2–related viruses (eg, severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses and influenza virus H5N1) showed that antiseptic solutions containing chlorhexidine gluconate, polyvinylpyrrolidone iodine, chlorine dioxide, cetylpyridinium chloride, and hydrogen peroxide can indeed reduce viral loads [7]. We found that different SARS-CoV-2 strains can be efficiently inactivated with commercially available oral rinses under biologically relevant conditions mimicking respiratory secretions. In particular, we observed that 3 formulations (products C, E, and F) containing different active compounds significantly reduced viral infectivity to undetectable levels. In agreement with our observation, different studies using Listerine (product F) observed antiviral activities specifically against enveloped viruses, implying an impact on the viral lipid envelope [8–10]. The in vivo effects of the oral solutions require further analysis during clinical studies.”

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454736/

    “For mouthwashes based on essential oils, complete inactivation of
    SARS-CoV-2 was demonstrated with alcohol content (Listerine Cool Mint)
    as well as without (Listerine Cool Mint mild taste) [12].
    In contrast, mouthwashes based on hydrogen peroxide, polihexanide,
    chlorhexidine or octenidine (the latter without the combination with
    phenoxyethanol) were not sufficiently effective [10].”

    https://europepmc.org/article/MED/33520603#R12

    Abstract

    “The mechanism of activity and the antiviral spectrum of Listerine antiseptic have not been examined thoroughly. We therefore tested its effect on laboratory strains of herpes simplex type 1 and type 2 (enveloped DNA viruses), influenza A virus (enveloped RNA virus), rotavirus (nonenveloped RNA virus), and adenovirus type 5 (nonenveloped DNA virus). Each virus was mixed with an equal volume of Listerine for 30 seconds to 5 minutes, and the residual infectivity of the virus was assessed. An antiviral effect was defined as greater than 95% reduction of infectivity. Exposure to Listerine for 30 seconds had an antiviral effect against herpes simplex type-1 and type-2 (96.3% and 100% reduction in infectious virus, respectively) and influenza A (100% reduction). In contrast, rotavirus-induced plaque formation was reduced by 12.2% after 30 seconds of exposure to Listerine, whereas 5 minutes of exposure to Listerine resulted in a 21.5% increase in plaque formation. Exposure of adenovirus to Listerine had a minimal effect on the cytopathocity of the virus…”

    https://pubmed.ncbi.nlm.nih.gov/7614202/

    Virucidal gargling and virucidal nasal spray. – Europe PMC

    https://europepmc.org/article/MED/33520603

    After 1 minute of exposure to green tea and pomegranate juice, the infectiousness of the viruses is reduced by 80% and by 97% with aronia juice .


  • Avatar

    IveyTech

    Member
    May 1, 2021 at 8:10 pm

    The same ongoing problem of waiting for Clinical Trials for the “official” endorsement continues.

    Can the general population get past this and take responsibility for health choices on an individual basis?

    LISTERINE RESPONDS

    https://www.listerine.com/covid-19-update

    “Although there are recent lab-based reports (in vitro studies) of some LISTERINE<sup>®</sup> Mouthwashes having activity against enveloped viruses, including coronavirus, the available data is insufficient, and no evidence-based clinical conclusions can be drawn with regards to the anti-viral efficacy of LISTERINE<sup>®</sup> Antiseptic mouthwash at this time.”

    “Our understanding of the course of COVID-19 disease transmission continues to evolve. More research is needed to understand whether the use of mouthwashes can impact viral transmission, exposure, viral entry, viral load and ultimately affect meaningful clinical outcomes.”

    “As a company firmly rooted in science, we are actively participating in scientific dialogue with study investigators around the globe.”

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