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  • TheRealRestoreInc.

    Member
    December 3, 2021 at 12:23 am

    Manipulation of stem cells, RNA and other body molecules

    This site is about research into various synthesized RNA molecules.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450780/

    This site is about conception, making eggs from stem cells

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    Excerpts

    “Since delivery is a well-recognized challenge for RNA research and drug development (Crooke, Wang, Vickers, Shen, & Liang, 2017; Dowdy, 2017; Kanasty, Dorkin, Vegas, & Anderson, 2013), utilization of the right RNA molecules has been overlooked for decades (Duan & Yu, 2016; P. Y. Ho & Yu, 2016). Currently, chemically engineered/synthesized oligonucleotides or RNA ‘mimics’ dominate RNA research and drug development, and some have been successfully approved by the FDA for clinical practices (Table 1). However, these ‘mimics’ are decorated with various and extensive chemical modifications (Bramsen & Kjems, 2012; Khvorova & Watts, 2017; Lundin, et al., 2013; Winkler, 2013), making them totally different from natural RNAs transcribed from the genome and folded in living cells that carry no or minimal posttranscriptional modifications (Cantara, et al., 2011; Limbach, Crain, & McCloskey, 1994; Morena, Argentati, Bazzucchi, Emiliani, & Martino, 2018). The use of chemo-engineered RNA mimics for research and development is also in sharp contrast to protein research and therapy (Leader, Baca, & Golan, 2008; Secher, et al., 2018), and the latter has proven to be highly successful by preferentially using biologic or recombinant proteins produced and folded in living cells rather than polypeptides or proteins synthesized in vitro via peptide chemistry. “

    “The use of synthetic RNA mimics for RNA research and drug development is also in contrast with the ultimate success of protein research and therapy utilizing biologic or recombinant proteins produced and folded in living cells instead of polypeptides or proteins synthesized in vitro.”

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