MemberApril 18, 2021 at 4:59 pm
There is a possible SARS-CoV-2 drug derived from research on feline coronavirus disease.
MemberApril 18, 2021 at 5:06 pm
Remdesivir’s approval during cat coronavirus research results is profit driven.
Later approved under EUA for COVID-19.
“While most animals with feline infectious peritonitis don’t show symptoms, some cats can develop severe illness if the virus mutates to infect a specific type of immune cell. When that happens, the coronavirus spreads throughout the cat’s body, sparking a deadly inflammatory reaction that can cause paralysis or fluid to accumulate in the lungs.
In that way, the cat coronavirus is similar to SARS-CoV-2. Both severe COVID-19 in people and feline infectious peritonitis cases are driven by a dysfunctional inflammatory immune response, says Julie Levy, a veterinarian at the University of Florida in Gainesville.
GC376 works by preventing a key enzyme called M protease, which is found in a number of different coronaviruses, from chopping up long strings of viral proteins. RNA viruses like SARS-CoV-2 often make such protein strings that protease enzymes snip into smaller pieces that then help the virus make more of itself in a cell (SN: 3/10/20). Hindering the protease’s ability to cut can halt viral replication.
In a 2016 study, six of eight cats recovered from an infection with the deadly form of the feline coronavirus after treatment with the drug, Pedersen and colleagues reported in PLOS Pathogens. The two cats that died were among four that had developed severe symptoms, such as jaundice and high fever. But those cats may have suffered from complications of a separate drug they were given to alleviate the disease, the team wrote…”
“…Researchers including Jun Wang, a chemist who studies antiviral drug development at the University of Arizona in Tucson, have found that GC376 can stop the SARS-CoV-2 protease from working in a test tube. Wang, who reported those results June 15 in Cell Research, says his team is now testing the compound in mice. And in results presented August 4 at the virtual American Crystallographic Association meeting, biochemist Joanne Lemieux and colleagues revealed that GC376 not only inhibits the SARS-CoV-2 enzyme in a test tube, but can also hinder viral replication in lab-grown monkey cells. Those results were also posted May 5 at bioRxiv.org.
Based on those findings — and the fact that the drug is safe and effective in cats — the company that makes GC376, Anivive Lifesciences, based in Long Beach, Calif., is now working to move forward with clinical trials in people, says Lemieux, of the University of Alberta in Edmonton, Canada.
“The fact that this drug has already been developed and shown to be successful in treating feline infectious peritonitis, it really bodes well,” Lemieux says.
The other cat drug, GS-441524, that has been effective against the feline coronavirus is similar to remdesivir. The compounds have a similar chemical structure, though remdesivir has an additional part that better helps it get into cells.
Both remdesivir and GS-441524, drugs developed by the biopharmaceutical company Gilead Sciences, based in Foster City, Calif., mimic a building block of the genetic molecule RNA, which makes up the coronavirus’s genetic material. As the virus replicates, it incorporates the copycat building block into its RNA, which prevents viral enzymes from adding more building blocks, stopping replication (SN: 7/13/20).
Pedersen and his colleagues reported that GS-441524 is an effective treatment for feline infectious peritonitis in June 2018 in Veterinary Microbiology. The drug not only inhibited viral replication in lab-grown cells, but also successfully treated 10 out of 10 coronavirus-infected cats that developed severe disease. In a separate February 2019 study in the Journal of Feline Medicine and Surgery, 25 of 26 cats treated with the drug for at least 12 weeks survived.
There is also some evidence hinting that GS-441524 could help people with COVID-19, too. A July 21 study in Cell Reports found that the drug can inhibit SARS-CoV-2 replication in lab-grown monkey and human cells. Remdesivir, however, was more potent in human lung cells, while GS-441524 was more potent in the monkey cells.
Despite such promising results in cats, the drug isn’t legally available for use in those animals. And by focusing instead on remdesivir, which is a complex molecule that is more difficult to make, critics say the company is focusing on a potentially more lucrative drug and so putting its profits ahead of public health. Gilead didn’t respond to questions from Science News about licensing GS-441524. But the company has noted that it was in a position to move quickly with remdesivir because the drug had already cleared human safety trials…”
MemberApril 18, 2021 at 5:07 pm
MemberApril 18, 2021 at 5:54 pm
The news tried to calm you…
We do not know the exact source of the current outbreak of coronavirus disease 2019 (COVID-19), but we know that it originally came from an animal, likely a bat. At this time, there is no evidence that animals play a significant role in spreading SARS-CoV-2, the virus that causes COVID-19, to people.
Apr 1, 2020The team, at Harbin Veterinary Research Institute in China, found that cats are highly susceptible to Covid-19 and appear to be able to transmit the virus through respiratory droplets to other cats.
MemberMay 2, 2021 at 12:35 pm
<div><b itemprop=”headline”>Human Can Transmit COVID-19 Virus to Cats: It’s Confirmed Now
April 23, 2021
<b itemprop=”description”>According to the
available information, ferrets, cats, civets, and dogs are the most
susceptible animals to SARS-CoV-2. Most of these animals became infected
after contact with people with COVID-19.
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