- MemberJuly 27, 2021 at 8:28 pm
The Non-natural or random gain of function of SARS-CoV-2’s origin virus was not planned, nor a conspiracy to make China have a social credit score system and the USA flirt with ARPA-H, a biomedical surveillance system.
But the appearance of SARS-CoV-2 as a natural pandemic, must lead to our resistance of governments using a crisis to own us.
Excerpt from This Biden Proposal Could Make the US a “Digital Dictatorship”
Facebook was shaped in its early days to be a private-sector replacement for DARPA’s controversial LifeLog program, which sought to both “humanize” AI and build profiles on domestic dissidents and terror suspects. LifeLog was also promoted by DARPA as “supporting medical research and the early detection of an emerging pandemic.”
It appears that current trends and events show that DARPA’s decades-long effort to merge “health security” and “national security” have now advanced further than ever before. This may partially be because Bill Gates, who has wielded significant influence over health policy globally in the last year, is a long-time advocate of fusing health security and national security to thwart both pandemics and “bioterrorists” before they can strike, as can be heard in his 2017 speech delivered at that year’s Munich Security Conference. That same year, Gates also publicly urged the US military to “focus more training on preparing to fight a global pandemic or bioterror attack.”
In the merging of “national security” and “health security,” any decision or mandate promulgated as a public health measure could be justified as necessary for “national security,” much in the same way that the mass abuses and war crimes that occurred during the post-9/11 “war on terror” were similarly justified by “national security” with little to no oversight. Yet, in this case, instead of only losing our civil liberties and control over our external lives, we stand to lose sovereignty over our individual bodies.
- MemberJuly 27, 2021 at 8:49 pm
…We are in an investigation about the origin of SARS-CoV-2 that will never be settled.
What precedent do I have for saying that? It is this — people are not settled on other origin hypotheses, including the origin of Man.
- MemberJuly 31, 2021 at 10:56 pm
If we settle that the origin of SARS-CoV-2 is lost to historians and all that we have are reactions and responses to SARS-CoV-2…perhaps we should look at the responses that seem to thrive on the existence of SARS-CoV-2.
Is this organization going to grow as a result of SARS-CoV-2? What other organizations benefit from the existence of SARS-CoV-2? What individuals benefit from the existence of SARS-CoV-2?
Here is the problem: profit.
It is not as clear as simplistic conspiracy theorists might make it appear, for “Cui bono” can extend to the innocent…when you consider profit. Just basic employment muddies the waters of conspiracy theories, so one must separate out profit obtained from basic employment from the criminal intent “mens rea” category, otherwise the following analogies would be grounds for guilty parties:
People profiting monetarily from SARS-CoV-2 include…
a nurse, because she is employed to treat patients with COVID-19, works more OT hours, is now able to profit on sick people
a residential trash truck employee, because people are staying home more and generating garbage, starting or continuing service, becomes “an essential employee”
a liquor store owner sells more alcohol during pandemic, profiting from disease
a pharmaceutical researcher seeking a novel treatment for diseases, works on a COVID-19 cure, gets paid
Let’s look at that very LAST category of employment. The others are not logical suspects. Let’s add some more jobs:
CEO of World Economic Forum trying to organize the world’s economy gets more attention the more SARS-CoV-2 spreads
Media corporation accountants and mangers, looking to stay profitable, choose alliances with businesses and government that will keep them in the black during pandemic.
Sometimes it is clear that we all suffer, othertimes it is clear that the “person” who is on the forefront of not letting a crisis go to waste is manipulating the true history of the pandemic, and forcing the outcome to go into a direction determined by other “persons” in collusion with the first “person” and with each other.
This is a close to a non-criminal definition of “conspiracy” as you can get. At what point does the collusion become “not letting a crisis go to waste” in a racketeering kind of way?
Science can be a field of racketeering.
There is the profit motive.
There is the funding conflict of interest.
There is the consensus approval pressure.
And there is revolving-door employment.
Enter Regina Dugan, and enter..
Led by Leap CEO, Regina E. Dugan, who served as the 19th Director of DARPA, where she oversaw an annual $3B portfolio of projects ranging from hypersonics to RNA-based vaccines.An experienced Silicon Valley executive, she also built and led advanced project organizations at Google and Facebook. Chaired by one of the most effective business leaders in the life sciences industry, Jay Flatley.
Are there any citizens in the USA who have the samr level of rights as Regina E. Dugan?
Sure, we citizens all have emumerated and unenumerated rights and are protected by the Law of the Land.
But somehow, the “corporate persons” Google, Facebook, DARPA — all have come to the spotlight during this pandemic. And all these “corporate persons” are colluding with one another, influencing millions of individual natural persons, with communications software, communications hardware, social media, pandemic information, vaccinations, and more.
Is this clear — that one natural person’s rights do not get amplified or exponentially greater — by acting a corporate CEO?
Let’s then go back to Origin of coronavirus.
The authentic, original virus that was in a natural setting is not even important.
The first mutation of virus that infected a human, IS important, but is dead now, and its reproduced descendants that were identified and determimed to cause COVID-19 disease..are now the fuel that a “corporate person” such as Wellcome Leap Inc. is attempting to grow on.
We don’t all see the Origin of SARS-CoV-2 with the same hypothesis. But the future desire for life, liberty and happiness, for a person of natural origin, should be greater than for an entity of “corporate personhood”.
Some natural persons are pleading for the justice that makes corporate persons back off so it is an environment to speak about all this again.
A “Leap” toward Humanity’s Destruction
The world’s richest medical research foundation, the Wellcome Trust, has teamed up with a pair of former DARPA directors who built Silicon Valley’s skunkworks to usher in an age of nightmarish surveillance, including for babies as young as three months old. Their agenda can only advance if we allow it.
June 25, 2021
27 minute read
A UK nonprofit with ties to global corruption throughout the COVID-19 crisis as well as historical and current ties to the UK eugenics movement launched a global health-focused DARPA equivalent last year. The move went largely unnoticed by both mainstream and independent media.
The Wellcome Trust, which has arguably been second only to Bill Gates in its ability to influence events during the COVID-19 crisis and vaccination campaign, launched its own global equivalent of the Pentagon’s secretive research agency last year, officially to combat the “most pressing health challenges of our time.” Though first conceived of in 2018, this particular Wellcome Trust initiative was spun off from the Trust last May with $300 million in initial funding. It quickly attracted two former DARPA executives, who had previously served in the upper echelons of Silicon Valley, to manage and plan its portfolio of projects.
This global health DARPA, known as Wellcome Leap, seeks to achieve “breakthrough scientific and technological solutions” by or before 2030, with a focus on “complex global health challenges.” The Wellcome Trust is open about how Wellcome Leap will apply the approaches of Silicon Valley and venture capital firms to the health and life science sector. Unsurprisingly, their three current programs are poised to develop incredibly invasive tech-focused, and in some cases overtly transhumanist, medical technologies, including a program exclusively focused on using artificial intelligence (AI), mobile sensors, and wearable brain-mapping tech for children three years old and younger.
This Unlimited Hangout investigation explores not only the four current programs of Wellcome Leap but also the people behind it. The resulting picture is of an incredibly sinister project that poses not only a great threat to current society but to the future of humanity itself. An upcoming Unlimited Hangout investigation will examine the history of the Wellcome Trust along with its role in recent and current events.
Endnote: YES, Origin matters, but current and future health choice rights, economic freedom of persons, reduction of the pandemic’s spread and the virus’ ability to kill or permanently disable — must all be addressed with preventative measures that are real world experience proven.
The future is determined by each natural person and our Constitutional republic is still the defined ORIGIN of the USA.
Responsibility for the outbreak or for the extinction of the virus is yours, one natural person at a time. We do not all have the exact same hypotheses, but we can do what works for our own selves, without leading others into destruction.
- MemberAugust 1, 2021 at 9:31 am
ORIGIN OF SARS-CoV-2 not as important as future reactivity to the fears that are present…
On the one hand are complaints about conspiracy theories, on the other, complaints about corporate collusion and conflictscof interest.
Clinical Trials results and Real World Evidence documentation should be combined, not compartmentalized.
POSTED ARTICLE BELOW GIVES VOICE TO ONE OF THE “COVID-19 MISINFORMATION SOURCES” so that science can be open, free debate on the COVID-19 pandemic origin and response, as well as our planet’s future.
| July 22, 2021
| by DR. JOSEPH MERCOLA
<small>Posted on 07/22/2021 11:03:05 AM PDT by <font color=”black”>Red Badger</font></small>
Editor’s Commentary: One of the things that makes Dr. Joseph Mercola and independent journalist Whitney Webb so special is their willingness to speak the truth at great personal cost. But if there’s one complaint, it’s that they often “bury the lede” and leave the readers or viewers to connect the dots. Some of this is due to politeness, but it’s mostly due to concerns over censorship, cancel culture, and financial repercussions.
Perhaps I’m just a glutton for censorship but I’ll come right out and say what most of you already know. Google is an evil company comprised of a combination of evil people and useful idiots. But based on the bombshell allegations in the article and video below, they may be even more evil than I ever thought, and that’s saying a lot.
What do transhumanism, globalism, and Neo-Marxism have in common? Well, a lot actually, but one common tie that binds at the very top of the dastardly pyramid is Google, or more specifically their parent company, Alphabet. And what else do these things have in common? Yes, the Covid-19 “vaccines” that every “arbiter of truth” in the world right now is pushing onto the masses. There are plenty of conspiracy theories about what exactly drives this push. What’s the endgame? Whatever the path that these “vaccines” take the world down, we know with an absolute certainty that it’s not going to be good for any of us whether we’re persecuted for not getting vaxxed or if we suffer through the eventual repercussions of the shots themselves.
As usual, I do not agree 100% with everything that Dr. Mercola and Webb expose about Google and others in the video and article below. But I’m not seeking purity through absolute agreement; we’re individualists, not collectivists. We can all take slightly different paths in our pursuits of the truth. As long as the bulk of what is being shared is correct, the nuances are secondary. With all that said, here’s the good doctor and journalist to tell the story…
The Latest Google Censorship Due to Their Vaccine Investment
* YouTube’s parent company, Google, is directly invested in the AstraZeneca/Oxford COVID “vaccine.” This is why YouTube censors anything that threatens the rollout and future profits of COVID-19 gene modification therapies
* Silicon Valley has been pushing to transform the health care system into a system based on telemedicine and personalized care through the use of artificial intelligence (AI). Google is heavily involved in this movement
* Google is also partnered directly with the U.S. military, which is increasingly working on a transhumanist agenda
* DARPA is heavily invested in transhumanist technologies for the use in soldiers, including brain-machine interfaces and other even more extreme ideas. They recently teamed up with the Wellcome Trust to create something called “Wellcome Leap,” a movement to usher in transhumanism
* Normally, there are very strict rules and regulations surrounding the testing and use of gene modification technology in humans. It’s only because they’re calling the COVID shots “vaccines” that they were able to get the EUA, which allows some standard safety regulations to be bypassed
VIDEO AT LINK…………….
In the video above, German attorney and co-founder of the German Corona Extra-Parliamentary Inquiry Committee (Außerparlamentarischer Corona Untersuchungsausschuss1),2,3 Dr. Reiner Fuellmich,4 interviews Whitney Webb, an independent investigative reporter, about who’s really behind YouTube’s censorship of medical researchers and their published works.
He recounts how a medical doctor who after a great deal of trouble managed to get a risk-benefit analysis of mask mandates published in the Journal of Pediatrics. He created a short video about his findings, and within minutes of posting it to YouTube, the video was removed. What is actually going on here? Who is behind the censoring of peer-reviewed science? Who is trying to influence what?
Google Is Invested in the COVID ‘Vaccine’
As noted by Webb, YouTube’s parent company, Google, is directly invested in the AstraZeneca/Oxford COVID “vaccine.” While the AstraZeneca jab has been framed as a not-for-profit product, this is far from true. The developers of this gene modification tool are Adrian Hill and Sarah Gilbert with the Jenner Institute for Vaccine Research.
While the Jenner Institute is the official developer of the shot, the actual patents and royalty rights for the AstraZeneca shot are held by a private company called Vaccitech, which was founded by Hill and Gilbert. Vaccitech’s investors include:5,6,7,8
The Wellcome Trust, which has longstanding links to the eugenics movement The British government
BRAAVOS, a capital investment company set up by a Deutsche Bank executive. BRAAVO’s investment is partially hidden, as BRAAVO is the main shareholder of Oxford Science Innovation, which in turn is invested in Vaccitech
Chinese interests, including a Chinese bank branch and a drug company called Fosun Pharma
All of these investors stand to profit from this “vaccine” at some point in the near future, and Vaccitech has been quite open about the future profit potential with its shareholders, noting that the COVID-19 shot will most likely become an annual vaccine that is updated each season much like the seasonal flu vaccine.
Sure, AstraZeneca promised it would not make any profit from this COVID-19 vaccine, but there’s a time limit on this pledge. The not-for-profit vow expires once the pandemic is over, and AstraZeneca itself can decide when that is.
Google Is Protecting Its Financial Stakes
Since Google has a direct financial interest in AstraZeneca’s COVID-19 “vaccine,” is it any wonder that its subsidiaries, like YouTube, are censoring information that threatens the future profitability of these products? I would think not.
More broadly, Silicon Valley has been pushing to transform the health care system as a whole into a system based on telemedicine and artificial intelligence (AI). Essentially, they’re looking to replace doctors with AI-driven apps and the like.
“They’ve started to sort of reimagine health care as a way of taking control over people’s lives, telling them it’s for the benefit of the public, the collective, and also their personal health, whereas it’s really a way to implement these transhumanist or technocratic technologies under the guise of that being a health-related venture,” Webb says.
Google, of course, is intimately involved in all of this. They’re also partnered directly with the U.S. military. “So, the fact that they’re censoring stuff that goes against the narrative that they want to put forth on matters relating to public health … really shouldn’t surprise anyone,” Webb says.
Johnson & Johnson
Johnson & Johnson’s COVID shot, meanwhile, is manufactured by an American company called Emergent BioSolutions, which was previously called BioPort. According to Webb, BioPort was created as a spinoff of the British biodefence facility at Porton Down.
In her April 2020 article, “A Killer Enterprise: How One of Big Pharma’s Most Corrupt Companies Plans to Corner the COVID-19 Cure Market,”9 Webb details the scandal-ridden history of BioPort and its role in the 2001 anthrax attacks and the opioid crisis. The company was rebranded as Emergent BioSolutions in 2004. In the featured video, she says:
“They were intimately involved in what happened with the 2001 anthrax attacks, because it was basically the only way they were going to manage to save their mandatory — for U.S. military personnel — anthrax vaccine program,” she says.
“They’ve been involved in scandals really ever since then … but were chosen to manufacture [the Johnson & Johnson COVID shot] despite that, and the person they put in charge of quality control at this facility that was manufacturing these Johnson & Johnson vaccines has no experience in that at all, or really in the field of any sort of pharmaceutical development or chemistry.
His background is being head of military intelligence teams for the U.S. military in Iraq and Afghanistan. [He] is also an expert on Iran and North Korea …
More recently, the scandal that’s developed in the U.S. with the Johnson & Johnson vaccine is that these batches were ‘ruined,’ they say basically unusable, and who knows what would have happened to people if that had been widely used …
Of course, they gave Johnson & Johnson a pass on that, and the blame has been placed on Emergent BioSolutions, but of course, nothing has really been done to them as a company. They’re intimately connected to the U.S. military and also to the CIA and a military contractor in Ohio, Battelle, which has a lot of ties to the anthrax attacks as well.”
Many Unanswered Questions
One of several deep concerns raised in this interview is whether there are any independent controls or reviews of the contents of these COVID jabs. What’s really in them? Dr. Wolfgang Wodarg, German physician and epidemiologist, asks. They’re all used under emergency use authorization (EUA), which allows many standard controls to be bypassed.
Wodarg wonders whether the drug industry may simply be using the EUA to learn more about how the mRNA technology actually works, using the public as guinea pigs.
Normally, there are very strict rules and regulations surrounding the use of gene modification technology in humans. It’s only because they’re calling them “vaccines” that they were able to get the EUA that allows a lot of standard safety regulations to be bypassed.
Wodarg points out that, based on the declared ingredients, there does not appear to be any way to explain the magnetism that thousands of people around the world are now reporting, where magnets, keys, cutlery, coins, cellphones and any number of other things stick to their bodies.
The phenomenon appears to begin right around the injection site but, then, after a number of weeks, more or less their whole body becomes magnetized (although “magnetized” isn’t entirely accurate, as many nonmagnetic items will stick to their bodies).
DARPA is heavily invested in transhumanist technologies for the use in soldiers, including brain-machine interfaces and other even more extreme ideas. They recently teamed up with the Wellcome Trust to create something called ‘Wellcome Leap,’ a rather unsettling movement to usher in transhumanism. So, who controls what goes into these shots? Wodarg points out that some injections have been found to be nothing but saline, which suggests some people are actually getting a placebo injection, even though they’re being told they’re getting the real thing and they’ve not signed up for a formal trial.
Are “undercover” studies being performed that we’ve not been told about? There are many unanswered questions about what’s really going on with this COVID “vaccine” rollout. Webb comments:
“There definitely needs to be more attention given to the manufacturers of the vaccine because the developers ostensibly just develop the formula, which is then given to the manufacturers who actually produce and create the vaccine that is injected into people.
In the case of the U.S., the main manufacturer, not just for the Johnson & Johnson vaccine, [but also] a few others, is that same company, Emergent BioSolutions, which has an awful track record. The Pentagon lost a lawsuit in 2004 where they were accused of using U.S. military personnel as lab rats in an experimental off-label use of that particular anthrax vaccine they were producing …
BioPort, now Emergent BioSolutions, have a lot of interlocking ties with the U.S. military, and also with the department of health and human services. In terms of the mRNA technology, I definitely agree that they seized on this opportunity to use it more widely. So, the hidden hand, I would argue, with the mRNA vaccine, is the U.S. military.
If you look at both the Pfizer and Moderna mRNA technology, those both really started with a significant investment in 2013, to both companies, from DARPA [Defense Advanced Research Projects Agency], which is the advanced research branch of the U.S. military …”
Google’s ‘DARPA’ Program
DARPA, Webb says, is also heavily invested in transhumanist technologies for the use in soldiers, including brain-machine interfaces and other even more extreme ideas. They recently teamed up with the Wellcome Trust to create something called “Wellcome Leap,” a rather unsettling movement to usher in transhumanism.
As mentioned, the Wellcome Trust has deep roots in the eugenics movement, making the collaboration doubly disturbing. For more on this, read Webb’s investigative report “A ‘Leap’ Toward Humanity’s Destruction.”10
Now, the CEO of Wellcome Leap, Regina Dugan,11 worked at DARPA. She began working there in 1996 and between 2009 and 2012 served as its first female director. She was the one who greenlighted the 2013 DARPA funding to Pfizer and Moderna. In 2012, she left DARPA to create a DARPA equivalent for Google called Advanced Technology and Projects (ATAP).
She later took on a similar project at Facebook, called Building 8. Wellcome Leap is basically slated to be a “global health DARPA,” Webb says, with all the transhumanist connotations that brings.
Getting back to the issue of undercover experiments taking place in an unsuspecting public, Wodarg is very concerned that COVID-19 “vaccine” makers may be experimenting with various amounts of lipid nanoparticles, which could help explain some of the acutely lethal effects, and perhaps even the transfer phenomenon that appears to be occurring between vaccinated individuals and unvaccinated ones.
Of course, we don’t know if secret comparison trials are being done without our knowledge. What we do know is that Moderna has been working on mRNA vaccine technology for many years, and had been unable to solve the nanolipid toxicity problem. When the dosage was too low, the mRNA didn’t stick around long enough for the drug to work, and when too high, it became toxic.
Despite years of work, they were never able to determine an effective nontoxic dose of mRNA in nanolipid. At least they never announced success. Now we’re supposed to take their word that they got it all figured out in less than a year? No, most likely, they never did figure it out and are using the cover of the pandemic to release an untested vaccine on the public under the guise of emergency use authorization.
Effective nontoxic dosing is probably what the public COVID vaccination campaign is going to help them determine, so that knowledge can then be applied to other gene modification drugs and vaccines. It’s convenient in the extreme, seeing how they are not accountable for any of the damage and death their products are causing, and their unremunerated human test subjects now number in the billions.
What Is the Vaccination Campaign Really About? According to Fuellmich, all the evidence currently suggests we’re not actually dealing with a medical emergency that would warrant the use of these gene modification tools, so the question is, why are they being pushed in such an unprecedented manner? There must be a reason for it, and if it’s not to address a medical emergency then what is it? Webb weighs in, saying:
“The Silicon Valley push to remake health care, a key part of that is what they call precision medicine … They describe it as medications and vaccines and gene therapies targeted to the individual, i.e., targeted to an individual’s own genome. This is why we’re seeing this increase, under the guise of COVID-19 testing, of this huge effort to amass genetic data of people across the world.
Of course, a lot of this is actually being held by the same Silicon Valley companies. In the case of the Western [part of] the U.S., a lot of COVID-19 testing has been done by Verily, which is a Google subsidiary, which at the same time is trying to make their AI health care based on this genetic data.
A lot of those same technologies for precision medicine also come from the U.S., military [and] involve predictive diagnoses where they say, based on an AI algorithm, you are likely to have this disease, whether it’s COVID or cancer or anything else, before you actually show symptoms of it.
That’s being co-developed right now by Google in a part of the military called the Defense Innovation Unit. There are lots of other examples of this going on. And so, I would argue that the wide-ranging use of these RNA vaccines, and treating them as regular vaccines instead of … gene therapy, is a way to normalize the same type of Silicon Valley-based precision medicine that they want to be the new normal in healthcare around the world.”
As you begin to unravel the interconnected web of players involved in this global vaccination campaign, you keep coming back to two key movements: the transhumanist movement and the eugenics movement, which in the mid-1950s actually began to merge. As noted by Fuellmich, it appears we’re observing “the coming out of a very long-running strategy” to reduce the population and alter those who are left.
“Yes, absolutely,” Webb says. “If you look back to someone like Julian Huxley, the [founding] director general of UNESCO and former president of the British Eugenics Society, which still exists today. It’s called the Galton Institute. They didn’t rename until 1989.
Adrian Hill of the AstraZeneca vaccine spoke at their 100-year anniversary, celebrating 100 years of … eugenics. The Wellcome Trust houses their archive, which they think is a great use to medicine in general.
Going back to Julian Huxley, in 1946 he said we should make the unthinkable thinkable again. Roughly 10 years later, he coined the term transhumanism and said that gene editing as a eugenics science needed to be applied along with … efforts to merge humans with machines as a way to create a new human being or human being 2.0 …
Recently, one of their board members … [published] a book that was actually positively reviewed and the UK press about eugenics in the 21st century. Front and center are these gene editing ‘medicines’ … I think it’s about control, and, ultimately … about eugenics.”
Webb goes on to discuss the January 2020 meeting of technocratic elites in Davos, Switzerland, at which an Israeli keynote speaker, Yuval Harari, warned we are entering an age of digital dictatorship where humans “are no longer mysterious souls — we are now hackable animals,”12 through the use of genetic engineering and advances in brain machine interface and technology. Needless to say, he urged the World Economic Forum members to make wise use of this technology.
It’s a very interesting discussion so, if you have the time, please do listen to the whole interview. In closing, Webb suggests that probably the best, most effective form or resistance is counter-economics. To joint together with others to produce what you need to survive, independent of the centralized systems and corporations that seek to control us.
“The most powerful protest at this point is going to be an economic protest,” Webb says. “Governments around the world are just waiting for more violent protest or riots. They have lots of tools and plans to deal with those. For example, in the U.S., they’re launching a war on domestic terror that is obviously going to target dissidence, from the way it is written …
That is the type of response that they’re expecting, whereas a passive nonviolent protest of economic resistance and counter-economics, just becoming independent of these people trying to build these systems [of control], I think is the most effective way to really counter it at this point.
And I think a broader counter-economics movement, in addition to a larger movement of people not consenting and just not engaging with the system, is something they fear a lot more, [which] I think could be really powerful.”
- MemberAugust 1, 2021 at 10:01 am
Here is the other side of the discussion of “From Origins of SARS-CoV-2 to the Future of Health Care and Surveillance”
Is the following statement TRUE or FALSE…or somewhere in between?
DARPA is heavily invested in transhumanist technologies for the use in
soldiers, including brain-machine interfaces and other even more extreme
ideas. They recently teamed up with the Wellcome Trust to create
something called ‘Wellcome Leap,’ a rather unsettling movement to usher
Let’s read what Wellcome Leap has to say:
Just as Sputnik ignited the Space Age, so too could the coronavirus inspire
The Health Age
Leap is built on a unique model of innovation practiced at DARPA.
For more than six decades, this model has been an uninterrupted engine of breakthrough innovation. It is not a discovery science model, but neither is it a pure application model. It sits firmly at the intersection of the two.
Work in what we call Pasteur’s Quadrant demands that we set ambitious goals that are measurable and testable. So that we’ll know if we succeeded or failed. It requires that we intersect life sciences and engineering, so that we can demonstrate advances at convincing scale — because that’s how an idea once thought impossible, is seen as possible.
Why does Leap’s model of innovation matter?
One of the primary elements of the model’s past success is its emphasis on bringing basic scientists and engineers together to work on a single project with bold goals and tight timelines. This creates a cauldron of activity that is driven by the urgency and demands of a global problem. This kind of work falls into what’s known as Pasteur’s Quadrant.
Opportunities in Pasteur’s Quadrant are perishable in time. Either the problem shifts or the science does. So speed and agility are important. And because the goals are ambitious, we most often require diverse ideas and a vibrant mix of participants working from their home organizations. This is almost a unique characteristic of Pasteur’s Quadrant projects, which are almost always multi-discipline, multi-community, multi-stage and dynamically adapting throughout the program.
This also requires strong partnerships, humility, and respect. Because work in Pasteur’s Quadrant depends on a robust basic science discovery engine and organizations that scale innovations in the public and private sector.
This strategy is described in more detail in “Special Forces Innovation: How DARPA Attacks Problems”, Harvard Business Review, Dugan & Gabriel, 2013.
“This is about being able to inject the cells in your muscles, say to
produce antibodies automatically, for a vaccine that we’ve never seen
before, and do it in 60 days or less to protect a large
population,” Walker said. “This is work we’ve been funding for about 10
years at universities, and now we are going into clinical trials with
this as we speak.”
<header itemscope=”itemscope” itemtype=”https://schema.org/WPHeader”>
© 2021 Wellcome Leap Inc.
- MemberAugust 1, 2021 at 11:48 am
If SARS-CoV-2 were intelligent and sinister to the level of having the motive to kill, not only by influencing its host cell to replicate, but also by influencing the host’s brain to ignore danger signs of backdoor infection when designing enhancement defenses (such as mRNA commands), resulting in breakthroughs by other variants.
The mRNA vs. natural immune system debate goes on, and the Origin of SARS-CoV-2 question isn’t that important compared to the discovery of prevention defenses. COVID-19 vaccines don’t prevent infections – they depend on the human immune system to ultimately do so.
Prophylaxis strategies and discoveries of “COVID killers” are being suppressed when “not approved”. Is this the virus planning this — no — the kind of humans that are turning against other humans who get well from other means, are worse than the SARS-CoV-2 virus — which the immune system can deal with — but one is perplexed by the absurd behavior of human corporations who oppose the preventative measures of individuals. Exercising choice, an individual is free to find his or her own survival approach, and continuing to find what works for an individual’s own good health is a primary, innate right. Finding out that gain-of-function of a virus was human triggered, is shocking, but breakthrough mutations triggered by injection of material into the human body, and adverse effects — including death — should be seriously considered to be the human mistake…if viruses are evasive while immunization campaigns continue, the viruses have won on that battlefront, but those of us whose prophylaxis is robust and kills the virus, have won the battle. I wish the global- level planners could see it.
The overreaching CORPORATE-GLOBAL view of health care choices doesn’t work completely. The right to choose or refuse is a natural person’s right in the USA. The Ninth Amendment alludes to rights people have had before human government existed. Unenumerated rights are as valid as enumerated rights in the USA, particularly when it comes to an individual pursuing LIFE, liberty and happiness, without infringing on “corporate personhood” or on other natural persons.
If a natural person becomes afraid, because of ignorance of the subject of prophylaxis, it follows that knowledge of the real world evidence of efficacy of prophylaxis compounds would alliviate those fears. Veterinary paste/gel 1.87% ivermectin is “Unapproved” because of ignorance of its efficacy against COVID-19 by FDA, yet that efficacy does not require that we know the ORIGIN of SARS-CoV-2, the FDA should consider that Nature provided the ORIGIN of ivermectin in Streptomyces Avermitillis bacteria in soil in Japan, and GAIN-OF-FUNCTION as an antiviral occurred by human efforts to isolate the efficacious portion of the bacterial molecules for beneficial purposes, including ANTIVIRAL PROPERTIES.
With that being said, I repeat, that the ORIGIN OF SARS-CoV-2 is unimportant, and GOF research on the virus is LESS IMPORTANT than using this prophylaxis Ivermectin (itself having a gain-of-function) as an anti-viral (instead of denying its antiviral properties, as the FDA does), with its aporoval it should certainly help to slow this pandemic and possibly end it, as successful as the Merck distribution if Mectizan has been.
It could be THAT simple.
Tell these people.
We need a global network of ‘living’ biofoundries.
Distributed, multi-product, RNA-based manufacturing capabilities will provide increased access to diverse biologics and sustainable pandemic response.
“Given this vaccine breakthrough, it would be reasonable to expect a wave of activity to discover, develop, and deliver new RNA-based biologics – a diversity of organizations; academic, small biotech, private and public research centers around the world flooding clinical facilities with novel, investigational products. All these products could then be tested against diseases that cause millions of deaths per year; thus providing access to these new products, while also securing protection against the next pandemic.
While we see continued and increasing global investments to scale existing mRNA manufacturing capabilities, such investments alone will not be enough to increase the number, diversity, affordability, and pace of discovery for these new biologic treatments, or to provide continuing access to agile, state-of-the-art manufacturing processes likely needed for rapid response to another pandemic.
What’s holding us back? The discovery and development of RNA-based products is still subject to the same, existing limitations chronically afflicting biologics: difficult access to current good manufacturing practices (cGMP) material for clinical trials as well as long and large investments (4-8 years and $300-$500 million dollars) in bespoke, manufacturing processes at dedicated facilities. This limits innovation and creates prohibitive production costs.
Today, RNA scientists trying to develop an innovative product are limited to using laboratory-grade materials in pre-clinical studies. Outside of one of the few biopharma corporations investing in cGMP for RNA-based biologics, most researchers have limited or no access to the know-how and resources required to develop a small-scale manufacturing process required for clinical trials. And even within those corporate environments, lacking a product with an expected net present value nearing a billion dollars, it would be challenging to get priority in the large-scale manufacturing strategy of the company.
R3 seeks to change the dynamics and costs of biologics development and production, addressing the limitations of current manufacturing by establishing RNA as a versatile, deployable, standardized, multi-product platform technology, that: 1) in non-emergency times provides developers and researchers with access to cGMP-formulated RNA for the development and production of a diversity of viable RNA-based products, and 2) in emergency times shifts to needed products at speeds & quantities sufficient to mount a globally coordinated, regionally focused response to a pandemic.”
What are a natural person’s rights to live a life of conscience and of self-health choices? We already have those rights.
The origin of SARS-CoV-2 is unimportant compared to the importance of overcomimg the virus by 1) your own health care choices (consent or refusal), 2) your education about what works for you and 3) your real world experience with what works for you. Scientists should be open to acknowledgement of what works, even though their hypotheses of how or why something they are pursuing SHOULD work…doesn’t completely hold true.
We have much to learn, often individually.
- MemberAugust 1, 2021 at 6:39 pm
<div>As promised, here’s the China Social Credit Score System that you don’t want in the USA:</div><div>
In April 2020 Dr Ai Fen, head of the emergency department at Wuhan Central Hospital, gave an interview to Chinese magazine Renwu. She described in great detail how, late in December 2019, she had begun receiving numerous patients into the emergency room with flu-like symptoms that were resistant to the usual treatments. She recounted how she “broke out in a cold sweat” when the first virus report of one of those patients came back. She hastily circled the words “SARS coronavirus”, screen-shot the report, and sent it to colleagues. Very quickly, her report circulated around Wuhan medical circles. But instead of mobilising the hospital and authorities, Dr Ai’s actions saw her reprimanded by the hospital disciplinary committee for “spreading rumours” and “harming stability”. Rather than warning staff and the public, hospital authorities told staff not to wear personal protective equipment and relayed instructions from the local health protection committee that, to avoid causing panic, doctors were prohibited from sharing messages and reports related to the virus.
But Dr Ai’s report was shared in a private post by another doctor, Li Wenliang, that later went viral on Chinese social media. As a result, Dr Li was temporarily detained by China’s “internet police”, which form part of the formal Chinese cybersecurity defence apparatus, and forced to sign a police document admitting that he had “severely disturbed the social order”. He later died of COVID-19 after treating numerous patients in Wuhan.
Dr Li’s death sparked outrage in China and was accompanied by calls for greater freedom of expression, government accountability, and opposition to online censorship.
Dr Li’s death sparked outrage in China and was accompanied by calls for greater freedom of expression, government accountability, and opposition to online censorship. Thousands of posts on messaging app WeChat and micro-blogging platform Weibo mourning the death and criticising authorities were not immediately suppressed by internet censors, echoing brief windows of openness that the Chinese Communist Party (CCP) allowed during previous times of crisis. The storm over Dr Li’s death also prompted China’s National Supervisory Commission to conduct an inquiry into the handling of early reports of the virus and Dr Li’s treatment. The official investigation report exonerated Dr Li, apologised to his family, and concluded that the police handling of his reprimand was inappropriate. Wuhan province-level officials were also removed from their posts.
But the same official investigation warned that “hostile forces with ulterior motives, who tried to stir up trouble, delude people, and instigate public emotions, are doomed to fail”. Censors began to remove internet posts and block trending hashtags #WeWantFreedomOfSpeech and #Wuhan Government Owes Dr Li Wenliang An Apology. With the help of artificial intelligence-powered search engine tools, the same internet police that silenced Dr Li were efficiently dispatched to pursue netizens who had written critically about the Chinese government’s handling of the outbreak and Dr Li’s treatment.
- MemberAugust 2, 2021 at 10:26 am
This “success” of China, using the Social Surveillance Reward and Punishment System — to contain the SARS-CoV-2 outbreak that started the worldwide pandemic — must consider the origin and the gain of function.
This is a list of research studies or commentaries on this big topic of origin-pandemic-consequences.