Florida State researchers received over $400,000 from the National Institutes of Health to investigate how closely children who receive a heart, liver or kidney transplant adhere to medication regimens post-surgery. The study data will originate from the Children’s Medical Center of Dallas’ Solid Organ Transplant Program.
One of the most significant predictors of late acute rejection (LAR) of organ transplants comes down to children not adhering to immunosuppressive medication prescriptions. They risk further hospitalizations, the need for replantation and even mortality among pediatric patients. Prior research suggests about 30% of children and adolescents do not follow their recommended immunosuppressive medication regimens post an organ transplant.
Data reveals that adolescents particularly struggle to comply with prescribed medication schedules and nonadherence is estimated to be double among this group versus younger children. But few studies have investigated longitudinal trajectories of immunosuppressive medication adherence and the possible differences in post-transplant outcomes. Hence, additional research is required along this studies lines and the form and variation in trajectories related to pediatric organ transplants.
The study sponsors seek to identify knowledge gaps by examining patient and familial factors, whether patients took medication as directed and post-transplant health outcomes in one of the largest pediatric transplant centers in the country. The data is from the Children’s Medical Center of Dallas’ Solid Organ Transplant Program. The teams goal: improve the accuracy in prediction of post-transplant outcomes.
The funding supports the investigators probe into patient compliance with immunosuppressive anti-rejection medications; whether divergent trends emerge post-transplant and type and nature of child and parent characteristics that might predict trends; how might these trends impact health outcomes?
Michael Killian, PhD, assistant professor at the FSU College of Social Work was awarded the two-year grant.
Yaacov Petscher, Director Biostatistical advisor
Zhe He, Assistant Professor, FSU College of Communication and Information (advisor)
Dr. Dev Desai, Children’s Medical Center of Dallas
Dr. Kelli Tripplett, PhD, Assistant Professor, Children’s Medical Center of Dallas
Dr. Eyal Shemesh, MD, Professor, Icahn School of Medicine at Mount Sinai