EIP Pharma Presents Results from AscenD-LB Study of Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies

EIP Pharma Presents Results from AscenD-LB Study of Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies

EIP Pharma presented results from the AscenD-LB phase 2 clinical study of their oral drug, neflamapimod, in mild-to-moderate dementia with Lewy bodies. Results demonstrated that neflamapimod treatment led to significant improvement relative to placebo in cognition, motor function and cognition & function. The data were presented at the 14th Clinical Trials in Alzheimer's Disease (CTAD) meeting. 

AscenD-LB was a double-blind, placebo-controlled, 16-week treatment in 91 patients with mild-to-moderate dementia with Lewy bodies. The study was conducted at 22 centers in the United States and two centers in the Netherlands. The patients were randomized to receive 40 mg neflamapimod capsules or matching placebo capsules (randomized 1:1) for 16 weeks. The dosing regimen was based on weight. The primary objective was to evaluate the effect of neflamapimod on cognition as assessed in a DLB-specific Neuropsychological Test Battery (NTB), designed to evaluate attention and executive function. Secondary endpoints included the Timed Up and Go (TUG) test and the Clinical Dementia Rating scale Sum of Boxes (CDR-SB).

Initial results presented at the 13th CTAD meeting ...

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