Delta Variant May Acquire Total Vaccine Resistance

Delta Variant May Acquire Total Vaccine Resistance

A new preprint study out of Japan titled “The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines” was published online on August 23. The first listed author is Yafei Liu, who works at the Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University and the Laboratory of Immunochemistry, World Premier International Immunology Frontier Research Centre Osaka. According to this paper, while our mRNA vaccines are effective against the most common SARS-CoV-2 variants, “identifying likely breakthrough variants is critical for future vaccine development.” The researchers found that the Delta variant escaped from anti-N-terminal domain (NTD) neutralizing antibodies and increased responsiveness related to anti-NTD infectivity-enhancing antibodies. Although, the Pfizer-BioNTech product BCT162b2 neutralized the Delta variant, “when four common mutations were introduced into the receptor-binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity.” Mutations in the Delta NTD were related to enhanced infectivity by the BNT162b2-immune ser...

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