Young Dana-Farber investigators Jennifer Guerriero, PhD and Sarah Hill, MD, PhD are on a mission to find better treatments for breast, ovarian and other cancers. Their research depends on patient tissue samples obtained by surgeons in Dana-Farber’s Susan F. Smith Center for Women’s Cancers.
Why are Tumors Vulnerable to Certain Drugs but not others?
Well this is a fundamental question the spirited investigators seek to answer. By exploiting normal and cancerous tissues—collected, banked and grown in the laboratory, the investigators examine the microenvironment of the tumor cells---e.g. the matrix of connective tissue and various types of cells interacting with the tumor cells—and seek to shed light on the role of immune cells surrounding the tumor. As it turns out, some of these cells can suppress an attack on the cancer while others can fuel the attack.
Breast Tumor Immunology Laboratory (B-TIL)
Guerriero is the director of the Breast Tumor Immunology Laboratory—known as B-TIL, which she has been building together with her mentor, Elizabeth Mittendorf, MD, PhD, the Rob and Karen Hale Distinguished Chair in Surgical Oncology and director of Dana-Farber’s Breast Immuno-...
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