Continued mass vaccination will only push the evolutionary capacity of SARS-CoV-2 Spike protein beyond the Omicron version

Note that views expressed in this opinion article are the writer’s personal views and not necessarily those of TrialSite.by G. Vanden Bossche, DVM, PhD

November 30th 2021   

‘Omicron is more infectious!’ ‘Omicron causes a milder course of disease!’ ‘Omicron escapes vaccine-mediated immunity!’ ‘Omicron has an astonishing number of mutations within the spike (S) protein!’ ‘Omicron will kill itself since it has too many mutations; these will end up incapacitating viral replication!’ ‘Omicron is ominous.’ ‘Omicron is harmless.’ ‘Omicron was bred by an HIV patient.’ ‘South-Africa is to be blamed for spreading Omicron!’ ‘Regardless of all the above, we need new vaccines: anti-Omicron vaccines! Such vaccines will tame Omicron, put a halt to the pandemic and force Omicron into endemicity!’

Neither Key Opinion Leaders (KOLs) nor public health (PH) understand anything related to the evolutionary kinetics of this pandemic; this hasn’t changed at all with the appearance of Omicron. Hard-core scientists spend much time on the molecular stamp collection of a plethora of steadily arising SARS-CoV-2 variants but can’t see the forest for the trees. Clinicians are puzzled by the different ...

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