Cleveland Led Principal Investigators Secure $10.4m to Study Differences in Glioblastoma between Males & Females

Cleveland Led Principal Investigators Secure $10.4m to Study Differences in Glioblastoma between Males & Females

Researchers from Case Western Reserve University School of Medicine and Cleveland Clinic’s Lerner Research Institute have secured $10.4 million over five years from the National Institutes of Health (NIH)/National Cancer Institute (NCI) to investigate at the molecular level the difference in glioblastoma between males and females. By delving into the genetics, epigenetics and cell biology of glioblastoma, the most common and deadly form of brain cancer in adults, the team hopes to better understand the physiologic processes which can point the way to powerful personalized therapies.

Glioblastoma: Rare but Deadly

Occurring at about 3.5-4 per 100,000 in America from 2012-16, glioblastomas are rare, according to the most recent data available from the Central Brain Tumor Registry of the United States (CBTRUS). Despite available treatments, glioblastomas have devastating consequences for patients. The median survival time is 12 to 14 months, and only about 5% of patients survive more than five years.

Previous Research

Previous research reveals differences between the genders as glioblastoma is 60 percent higher in males than females. Moreover, females appear to face better...

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