New research from the Cleveland Clinic and Case Western Reserve University has found that while newer strains and mutations of SARS-CoV-2 are often more contagious than the original COVID-19 strain, they may also be responsible for fewer hospitalizations and deaths.
Scientists from both Northeast Ohio institutions tracked genome sequences for SARS-CoV-2 between March 11-April 22, 2020, recently found that clades, which are subgroups of an initial strain, were associated with a higher mortality rate than those of newer origin.
This group of researchers, led by Dr. Frank Esper, a pediatric infectious disease physician at Cleveland Clinic Children’s, also included scientists who study cancer genomics, computer and data sciences, neurology and pathology, including Dr. Brian Rubin, chair of Cleveland Clinic’s Robert J. Tomsich Pathology and Laboratory Medicine Institute, and Jing Li, Ph.D., the Leonard Case Jr. Professor in Case Western Reserve University’s Department of Computer and Data Sciences.
“This study offers a detailed description of how the different COVID-19 clades evolved and competed once they were brought to Cleveland,”...
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